| 冠状病毒免疫逃逸机制研究进展 |
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| 引用本文： | 王荣花,郑志慧,张雨茜,闵锐,朱英,张评浒.冠状病毒免疫逃逸机制研究进展[J].中国药科大学学报,2021,52(1):1-9. |
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| 作者姓名： | 王荣花 郑志慧 张雨茜 闵锐 朱英 张评浒 |
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| 作者单位： | 扬州大学医学院转化医学研究院,江苏省中西医结合老年病防治重点实验室,扬州 225009,扬州大学医学院转化医学研究院,江苏省中西医结合老年病防治重点实验室,扬州 225009,扬州大学医学院转化医学研究院,江苏省中西医结合老年病防治重点实验室,扬州 225009,扬州大学医学院转化医学研究院,江苏省中西医结合老年病防治重点实验室,扬州 225009,扬州大学医学院转化医学研究院,江苏省中西医结合老年病防治重点实验室,扬州 225009,扬州大学医学院转化医学研究院,江苏省中西医结合老年病防治重点实验室,扬州 225009;扬州大学,江苏省人兽共患病重点实验室,扬州 225009 |
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| 基金项目： | 扬州大学高端创新人才资助项目(No.20180613);江苏省人兽共患病学重点实验室开放课题资助项目(No.R1707) |
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| 摘 要： | 冠状病毒是人和动物的重要致病原,其中新型冠状病毒肺炎(coronavirus disease 2019,COVID-19)给人类健康带来了致命威胁.宿主固有免疫反应是宿主抵抗病原体入侵的第一道防线,但过激的免疫应答也会加重病毒感染和病理损伤.病毒免疫逃逸是冠状病毒的重要致病机制.本文主要从宿主免疫传感器、干扰素、细胞因...
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| 关 键 词： | 冠状病毒 COVID-19 新型冠状病毒肺炎 宿主固有免疫反应 免疫逃逸 免疫传感器 干扰素 细胞因子 |
| 收稿时间： | 2020/12/29 0:00:00 |
| 修稿时间： | 2021/1/16 0:00:00 |
Progress of research on immune escape mechanism of coronavirus |
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| WANG Ronghu,ZHENG Zhihui,ZHANG Yuqian,MIN Rui,ZHU Ying and ZHANG Pinghu.Progress of research on immune escape mechanism of coronavirus[J].Journal of China Pharmaceutical University,2021,52(1):1-9. |
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| Authors: | WANG Ronghu ZHENG Zhihui ZHANG Yuqian MIN Rui ZHU Ying and ZHANG Pinghu |
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| Institution: | Key Laboratory of Geriatric Disease Prevention and Control of Jiangsu Province,Institute of Translational Medicine,School of Medicine,Yangzhou University,Yangzhou 225009,Key Laboratory of Geriatric Disease Prevention and Control of Jiangsu Province,Institute of Translational Medicine,School of Medicine,Yangzhou University,Yangzhou 225009,Key Laboratory of Geriatric Disease Prevention and Control of Jiangsu Province,Institute of Translational Medicine,School of Medicine,Yangzhou University,Yangzhou 225009,Key Laboratory of Geriatric Disease Prevention and Control of Jiangsu Province,Institute of Translational Medicine,School of Medicine,Yangzhou University,Yangzhou 225009,Key Laboratory of Geriatric Disease Prevention and Control of Jiangsu Province,Institute of Translational Medicine,School of Medicine,Yangzhou University,Yangzhou 225009,Key Laboratory of Geriatric Disease Prevention and Control of Jiangsu Province,Institute of Translational Medicine,School of Medicine,Yangzhou University,Yangzhou 225009;Jiangsu Key Laboratory of Zoonosis,Yangzhou University,Yangzhou 225009,China |
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| Abstract: | Coronavirus is an important pathogen of humans and animals. Among them, the novel coronavirus disease (COVID-19) breaking out in 2019 has brought a fatal threat to human health. The host"s innate immune response is the host"s first line of defense against pathogen invasion, but an excessive immune response can also aggravate viral infection and pathological damage. The immune escape of coronavirus is a critical pathogenic mechanism causing death. This work mainly reviews the pathogenic mechanism of coronavirus immune escape from several aspects such as host immunosensor, interferon, cytokine and coronavirus antagonizing host immune response, which provide a theoretical reference for the development of anti-coronavirus drugs. |
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| Keywords: | corornavirus COVID-19 novel coronavirus pneumonia host innate immune response immune escape immunosensor interferon cytokines |
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