地黄化学成分和药理作用的研究进展

地黄Rehmanniaglutinosa为我国民间传统植物药,有着久远的历史记载,主产于河南、河北、陕西、山西等地。其化学成分类型主要包括环烯醚萜类、紫罗兰酮类、苯乙醇苷类、三萜类、黄酮类及糖类等,对人体血液系统、心脑血管系统、中枢神经系统和免疫系统有显著作用。随着现代分离分析手段的不断创新,加之现代科学技术与药理学方法不断应用于地黄的药理作用及机理研究,近年来,地黄中的化学成分不断被发现,其药理作用进一步被开发,临床适用范围逐年扩大,引起了国内外科研工作者的热切关注。对地黄化学成分和药理作用的研究进展进行概述,旨在为传统中药地黄的进一步开发利用和现代化提供一定依据。

Research progress on chemical constituents and pharmacological actions of Rehmannia glutinosa

Dihuang (Rehmannia glutinosa) has been used as a traditional Chinese herbal medicine for thousands of years in China, which is mainly distributed in Henan, Hebei, Shaanxi and Shanxi Provinces. It mainly contains iridoids, ionones, phenylethanoid glycosides, triterpenoids, flavonoids, and saccharides, which has significant effects on human blood system, cardiovascular and cerebrovascular system, central nervous system and immune system. In recent years, with the development of innovative methods for separation and analysis, the modern science and technology and pharmacological methods were applied to study the chemical constituents and pharmacological action of R. glutinosa. More and more chemical components in R. glutinosa have been discovered, and its pharmacological actions have been further improved by development. Furthermore, the clinical application scope of R. glutinosa has been expanded year by year, which has aroused the keen attention of domestic and foreign scientific research workers. In this paper, the chemical constituents and pharmacological actions of R. glutinosa were summarized, in order to provide some basis for its further utilization and modernization.