阿尔茨海默病及轻度认知障碍所致脑灰质体积及脑功能改变

目的 基于体素形态学分析(VBM)及静息态功能MRI(rs-fMRI)技术观察阿尔茨海默病(AD)及轻度认知障碍(MCI)患者全脑灰质体积及功能改变.方法 对AD(AD组)、MCI患者(MCI组)各30例及正常老年人30名(HC组)采集rs-fMRI和三维磁化强度预备梯度回波序列T1加权像,比较3组全脑灰质体积、脑区分...

Alterations in gray matter volume and brain function in Alzheimer disease and mild cognitive impairment

Objective To investigate the changes of whole brain gray matter volume and brain function of Alzheimer disease (AD) and mild cognitive impairment (MCI) using voxel-based morphometry (VBM) and resting-state fMRI (rs-fMRI). Methods Thirty AD patients (AD group), 30 MCI patients (MCI group) and 30 age, sex and education level matched healthy old individuals (HC group) were enrolled and underwent rs-fMRI and three-dimensional magnetization prepared rapid acquisition gradient echo sequence scanning. The gray matter volume, fractional amplitude of low-frequency fluctuation (fALFF) and seed-based functional connectivity (FC) were compared among 3 groups. Results The gray matter volume of left superior temporal gyrus, bilateral middle temporal gyrus and parahippocampal gyrus were significant different among 3 groups, aso as values of the left calcarine, left caudate nucleus, left postcentral gyrus, right superior temporal gyrus, right superior parietal gyrus, left precentral gyrus, right precuneus gyrus, right middle frontal gyrus and postcentral gyrus (all P<0.05). Taken the left superior temporal gyrus as the seed point, increased FC in ipsilateral inferior temporal gyrus and contralateral inferior occipital gyrus were found in MCI and AD patients. Conclusion Combination of VBM and rs-fMRI technology was helpful to early diagnosis of MCI and AD. AD and MCI patients showed extensive reduction of fALFF values in the whole brain and increased FC in the ipsilateral temporal lobe and contralateral occipital lobe, AD patients were accompanied by a decrease in temporal lobe volume, while MCI patients showed no significant changes of gray matter volumes.