| 免疫检查点及其抑制剂在脑胶质瘤中的研究进展 |
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| 引用本文： | 陈文婷,柳军.免疫检查点及其抑制剂在脑胶质瘤中的研究进展[J].中国药科大学学报,2021,52(1):104-112. |
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| 作者姓名： | 陈文婷 柳军 |
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| 作者单位： | 中国药科大学新药筛选中心， 南京 210009,中国药科大学新药筛选中心， 南京 210009 |
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| 基金项目： | 国家自然科学基金资助项目(No.81973361) |
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| 摘 要： | 目前,脑胶质瘤的常规治疗尚不能显著改善患者预后,越来越多的研究人员开始关注免疫检查点抑制剂在脑胶质瘤中的治疗作用.本文主要综述了免疫检查点程序性死亡蛋白-1(PD-1)、程序性死亡蛋白配体-1(PD-L1)、细胞毒性T淋巴细胞相关抗原-4(CTLA-4)、T细胞免疫球蛋白和黏蛋白分子-3(TIM-3)、淋巴细胞活化基因...
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| 关 键 词： | 免疫检查点 免疫检查点抑制剂 免疫疗法 脑胶质瘤 |
| 收稿时间： | 2020/9/22 0:00:00 |
| 修稿时间： | 2020/12/14 0:00:00 |
Advances in research on immune checkpoint and its inhibitors in glioma |
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| CHEN Wenting and LIU Jun.Advances in research on immune checkpoint and its inhibitors in glioma[J].Journal of China Pharmaceutical University,2021,52(1):104-112. |
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| Authors: | CHEN Wenting and LIU Jun |
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| Institution: | Center of New Drug Screening, China Pharmaceutical University, Nanjing 210009,China,Center of New Drug Screening, China Pharmaceutical University, Nanjing 210009,China |
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| Abstract: | Conventional treatment of glioma has not significantly improved the prognosis of patients, so people pay more attention to the potential of immuno-checkpoint inhibitors in the treatment of glioma. This article reviews the expression and mechanism of some negative immune checkpoints in gliomas, such as programmed death-1 (PD-1), programmed death ligand-1 (PD-L1), cytotoxic T lymphocyte antigen-4 (CTLA-4), T-cell immunoglobulin and mucin-domain containing-3 (TIM-3), lymphocyte-activation gene-3 (LAG-3), T cellimmunoreceptor with Ig and ITIM domains (TIGIT), B7-H4 and V-domain immunoglobulin suppressor of T-cell activation (VISTA), as well as progress of immune checkpoint inhibitors in clinical research, with a prospect of their future in immunotherapy. |
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| Keywords: | immune checkpoints immuno-checkpoint inhibitors immunotherapy glioma |
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