| 血吸虫病化学治疗的研究——ⅩⅩⅩⅣ.α-氯-β-(5-硝基-2-呋喃)丙烯酰胺类及其乙烯噁二唑类衍生物的合成 |
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| 引用本文： | 王保钧,邓泳,马银凤,雷兴翰. 血吸虫病化学治疗的研究——ⅩⅩⅩⅣ.α-氯-β-(5-硝基-2-呋喃)丙烯酰胺类及其乙烯噁二唑类衍生物的合成[J]. 药学学报, 1987, 22(12): 923-928 |
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| 作者姓名： | 王保钧 邓泳 马银凤 雷兴翰 |
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| 作者单位： | 上海医药工业研究院 |
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| 摘 要： | Synthesis of 35 new compounds of α-chloro-β-(5-nitro-2-furyl) acrylamides and 5-[α-chloro-β-(5-nitro-2-furyl ) vinyl]-oxadiazoles by known methods are reported. In preliminary test in mice 10 compounds were found to possess pronounced activity against Schistosomiasis japonica. Among these Ⅰ12, Ⅰ13, Ⅰ14, Ⅰ20, Ⅱ1 and Ⅱ8 were shown to be the most effective.
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| 关 键 词： | 抗血吸虫病药 α-氯-β-(5-硝基-2-呋喃)丙烯酰胺类及其乙烯噁二唑衍生物 |
| 收稿时间： | 1987-01-09 |
Chemotherapeutic studies on schistosomiasis, XXXIV. The synthesis of derivatives of alpha-chloro-beta-(5-nitro-2-furyl) acrylamides and alpha-chloro-beta-(5-nitro-2-furyl) vinyl/oxadiazoles |
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| WANG Bao-Jun,DENG Yong,MA Yin-Feng and LEI Xing-Han. Chemotherapeutic studies on schistosomiasis, XXXIV. The synthesis of derivatives of alpha-chloro-beta-(5-nitro-2-furyl) acrylamides and alpha-chloro-beta-(5-nitro-2-furyl) vinyl/oxadiazoles[J]. Acta pharmaceutica Sinica, 1987, 22(12): 923-928 |
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| Authors: | WANG Bao-Jun DENG Yong MA Yin-Feng LEI Xing-Han |
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| Abstract: | Synthesis of 35 new compounds of α-chloro-β-(5-nitro-2-furyl) acrylamides and 5-[α-chloro-β-(5-nitro-2-furyl ) vinyl]-oxadiazoles by known methods are reported. In preliminary test in mice 10 compounds were found to possess pronounced activity against Schistosomiasis japonica. Among these Ⅰ12, Ⅰ13, Ⅰ14, Ⅰ20, Ⅱ1 and Ⅱ8 were shown to be the most effective. |
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| Keywords: | α-chloro-β-(5-nitro-2-furyl)acrylamides and α-chloro-β-[(5-nitro-2-furyl) vinyl]-oxadiazoles Schistosomicide |
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