Immunohistochemical localisation of keratin in human lung tumours |
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Authors: | Barry Gusterson Diana Mitchell Michael Warburton John Sloane |
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Institution: | (1) Ludwig Institute for Cancer Research (London Branch), Royal Marsden Hospital, SM2 5PX Sutton, Surrey;(2) Royal Marsden Hospital, SM2 5PX Sutton, Surrey, Great Britain |
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Abstract: | Summary Antisera against total keratin extracts of human callus have been used to identify keratins in lung tumours of different histological type. Forty-three were classified by the WHO scheme. Keratin immunoreactive cells were identified in all 8 epidermoid carcinomas; 6 out of 12 large cell carcinomas; 2 out of 6 adenocarcinomas; 2 out of 15 small cell carcinomas and in the only muco-epidermoid carcinoma. These cases demonstrate the heterogeneity of phenotypic expression in lung tumours not recognisable without the use of immunohistochemical techniques. |
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Keywords: | Keratin polypeptides Bronchogenic carcinoma Phenotypic modulation |
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