| 基于淋巴管系统在免疫调节中的作用探讨新冠病毒致肺损伤的机制及中药干预作用 |
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| 引用本文： | 梁倩倩,陈伟,徐浩,王腾腾,黄怡,石怡,陈锦漫,陈绍华,姚妙恩,鲍嘉敏,庄紫欣,李雪菲,施杞,王拥军. 基于淋巴管系统在免疫调节中的作用探讨新冠病毒致肺损伤的机制及中药干预作用[J]. 世界科学技术-中医药现代化, 2020, 22(2): 270-277 |
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| 作者姓名： | 梁倩倩 陈伟 徐浩 王腾腾 黄怡 石怡 陈锦漫 陈绍华 姚妙恩 鲍嘉敏 庄紫欣 李雪菲 施杞 王拥军 |
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| 作者单位： | 上海中医药大学附属龙华医院 上海200032;上海中医药大学脊柱病研究所 上海200032;教育部筋骨理论与治法重点实验室 上海200032;石筱山伤科学术研究中心 上海200032;施杞名中医工作室 上海200032;上海中医药大学附属龙华医院 上海200032;上海市重大危重医疗事件中西医协同响应与干预平台 上海200032;上海中医药大学附属龙华医院 上海200032 |
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| 基金项目： | 国家自然科学基金;国家自然科学基金;上海市医学领军人才;上海市曙光计划;教育部长江学者和创新团队发展计划项目;重点领域创新团队项目;上海市重中之重临床医学中心;上海市三年行动计划 |
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| 摘 要： | 新型冠状病毒肺炎所产生的炎性渗出,炎症风暴导致急性肺损伤,大量免疫细胞和组织液聚集肺脏,造成患者通气功能障碍,呼吸窘迫,甚至呼吸衰竭而死亡。调节免疫反应和减少肺组织渗出对控制该病的进展及促进后期康复至关重要。淋巴管系统具有免疫监视、免疫捕获和维持组织间液平衡的作用,在急性炎症反应过程发挥重要作用。本文综述淋巴管系统在肺部的分布、生理功能及其在急性肺损伤过程中的作用,结合本团队研究成果,探讨淋巴管系统在新型冠状病毒肺炎病理进程中的作用和机制,以及中医药疗法机制,为临床新型冠状病毒肺炎的治疗提供新思路和潜在治疗方案。
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| 关 键 词： | 新型冠状病毒肺炎 淋巴管系统 急性免疫反应 急性肺损伤 中医药治疗 |
Explore the Effect of Lymphatic System on Acute Lung Injury Caused by 2019-nCoV and the Potential Mechanism of Traditional Chinese Medicine Therapy |
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| Qianqian Liang,Wei Chen,Hao Xu,Tengteng Wang,Yi Huang,Yi Shi,Jinman Chen,Shaohua Chen,Miao’en Yao,Jiamin Bao,Zixin Zhuang,Xuefei Li,Qi Shi,Yongjun Wang. Explore the Effect of Lymphatic System on Acute Lung Injury Caused by 2019-nCoV and the Potential Mechanism of Traditional Chinese Medicine Therapy[J]. World Science and Technology—Modernization of Traditional Chinese Medicine and Materia Medica, 2020, 22(2): 270-277 |
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| Authors: | Qianqian Liang Wei Chen Hao Xu Tengteng Wang Yi Huang Yi Shi Jinman Chen Shaohua Chen Miao’en Yao Jiamin Bao Zixin Zhuang Xuefei Li Qi Shi Yongjun Wang |
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| Affiliation: | (Longhua Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200032;Spine Institute,Shanghai University of Traditional Chinese Medicine,Shanghai 200032;Collaborative response and intervention platform of Chinese and Western medicine for major critical medical events in Shanghai,Shanghai 200032;Key Laboratory of Theory and Therapy of Muscles and Bones,Ministry of Education of China,Shanghai 200032;Traumatological Academic Research Center of Shi Xiao Shan,Shanghai 200032;Famous Traditional Chinese Medicine Studio of Shi Qi,Shanghai 200032) |
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| Abstract: | 2019-n Co V pneumonia can give rise to causes inflammatory exudation and inflammatory storm.It can lead to a large number of immune cells and interstitial fluid assemble at the lung,and cause Ventilation dysfunction and respiratory distress,even death from respiratory failure.Regulation of immune response and reduction of pulmonary exudation are essential for the progression and prognosis of the disease.It is known that the lymphatic system is crucial for the immune surveillance,immune capture and maintenance of tissue fluid balance,and can play an important role in the process of acute inflammation.We reviewed the distribution,physiological function of lymphatic system in the lung and its role in the process of acute lung injury,including our previous researches,to explore the role and mechanism of lymphatic system in the pathological process of 2019-n Co V pneumonia and the potential effect of traditional Chinese medicine therapy.This review will provide new ideas,new targets and potential treatment options for clinical treatment of new coronavirus pneumonia. |
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| Keywords: | 2019 novel coronavirus Lymphatic vessel system Acute lung injury Acute immune response Traditional Chinese medicine therapy |
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