2型糖尿病患者抑郁情绪与糖化血红蛋白、血脂及其应对方式的研究

目的　探讨2型糖尿病患者抑郁情绪与糖化血红蛋白、血脂及其应对方式的关系。方法　根据Zung氏抑郁自评量表(self-rating depression scale, SDS)测定结果将73例2型糖尿病患者分为躯体+抑郁情绪组和躯体障碍组，并用焦虑自评量表(self-rating anxiety scale, SAS)进行验证考察。测定两组患者糖化血红蛋白（HbA1-c）、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C),同时进行医学应对问卷(medical copingmodes questionaire,MCMQ)评定。结果　躯体、抑郁情绪组TG、TC、LDL-C、SAS标准分、面对、回避、屈服的均值比躯体障碍组高，HbA1-c、HDL-C比躯体障碍组低,其中SAS和屈服的均值差异有统计学意义(P<0. 01)，两组间HbA1-c、血脂均无统计学意义。结论　2型糖尿病抑郁情绪与患者的焦虑情绪和使用屈服应对方式有关，与 HbA1-c、血脂无相关性。

Association of depression with glycosylated hemoglobin,lipid metabolism and coping style in patients with type 2 diabetes mellitus

Objective To investigate the association of depression with glycosylated hemoglobin, lipid metabolism and coping style in patients with type 2 diabetes mellitus (DM). Methods A total of 73 patients with type 2 DM were divided into depression group (n=31) and non-depression group (n=42) according to the Results of Zung Self-Rating Depression Scale. The anxiety statuses were evaluated by Zung Self-Rating Anxiety Scale(SAS). The coping style was assessed by Medical Coping Modes Questionnaire (MCMQ). Moreover, the blood HbA1c, triglycerides (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), and low density lipoprotein cholesterol (LDL-C) were also compared between the two groups. Results The SAS standard score and MCMQ score of resignation in the depression group were significantly higher than those in the non-depression group (P<0.01). The MCMQ score of confronce and avoidance, blood HbA1c, TG, TC, HDL-C, and LDL-C were not significantly different between the 2 groups. Conclusion It is suggested that type 2 DM patients with resignation coping style are more liable to have depression.