Inhibition of cholinergic histamine release in rat mast cells |
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| Authors: | R. Fantozzi E. Masini P. Blandina T. Bani-Sacchi L. Zilletti P. F. Mannaioni |
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| Affiliation: | (1) Department of Pharmacology and Toxicology, Florence University School of Medicine, Florence, Italy;(2) Department of Histology, Florence University School of Medicine, Florence, Italy |
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| Abstract: | Adrenaline inhibits the acetylcholine-evoked histamine release from isolated purified rat mast cells, in a dose-dependent fashion. The inhibitory effect of adrenaline is reversed by preincubating the cells with a beta-blocker, alprenolol, but not by preincubating them with an alpha-blocker, phentolamine. These results were confirmed by observations using an electron microscope and they suggest that adrenaline inhibits the cholinergic histamine release from rat mast cells acting upon beta-receptors. |
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