分阶段综合治疗胰头癌16例临床分析

分析减轻黄疸、介入化疗和手术切除“３阶段法”治疗大胰头癌的效果。方法收集本院近１年收治的１６例大胰头癌患者,采用上述“３阶段法”治疗。先行胆囊造瘘以缓解黄疸,１０ｄ－３个月后进行介入化疗尽量靠近胰十二指肠上下动脉,注入５氟尿嘧啶（５－ＦＵ）１－１．５ｇ,丝裂霉素８－１４ｍｇ、顺铂４０－６０ｍｇ,生长抑素１Ｕ。３周后进行手术结果１６例肿瘤均得以切除,其中常规胰十二指肠切除７例,区域性胰十二指肠切除９

Three steps procedure

OBJECTIVE: To evaluate the feasibility and effectivity of "3 steps procedure" in the treatment of large pancreatic head cancer. METHODS: The "3 steps procedure" consisted of decompression of jaundice by simple cholecystotomy, intervenient (intra-arterial) chemotherapy (5-FU 1 approximately 1.5 g, mitomycin 8 approximately 14 mg, cisplatin 40 approximately 60 mg and octreatide 1 mu intravenously as near the superior and inferior pancreatic-duodenal arteries as possible), and then the reasonable regional pancreatic-duodenectomy. RESULTS: All 16 tumors were radically resected. Conventional and regional pancreatic-duodenectomy was done in 7 and 9 patients, respectively; of the later group, artificial prosthesis for portal vein bridge was done in 3 patients, end-to-end anastomosis in 4 and repair after partial resection of invaded vessel wall in 2. CONCLUSION: The "3 steps procedure" is feasible and effective in the treatment of large pancreatic head cancer.