重复经颅磁刺激治疗老年性痴呆的效果及安全性

目的探讨重复经颅磁刺激(r TMS)对老年性痴呆(AD)患者认知功能的效果及安全性。方法以2015年1月-2016年10月在黑龙江省大庆市第三医院和大庆市龙南医院神经内科就诊,符合《国际疾病分类(第10版)》(ICD-10)诊断标准的60例AD患者为研究对象,采用最小不平衡指数法分为研究组和对照组各30例;研究组给予20 Hz r TMS治疗;对照组给予r TMS假刺激治疗。每周5次,共8周。治疗前后分别进行简易精神状态评价量表(MMSE)、蒙特利尔认知评价量表(Mo CA)、阿尔茨海默病评定量表认知分量表(ADAS-cog)评定。结果治疗前两组一般资料和MMSE、Mo CA、ADAS-cog评分比较差异均无统计学意义(P均0.05);治疗8周后,两组MMSE、Mo CA、ADAS-cog评分比较差异有统计学意义(P0.05)。结论高频(20 Hz)r TMS可能有助于改善AD患者认知功能,且安全性较好。

Efficacy and safety of repeated transcranial magnetic stimulation in the treatment of Alzheimer disease

Objective To investigate the efficacy and safety of repeated transcranial magnetic stimulation (rTMS) on cognitive function for Alzheimer disease(AD) patients.Methods A total of 60 AD patients were enrolled in two hospitals from January 2015 to October 2016, they met the diagnostic criteria of International Classification of Diseases,tenth edition(ICD-10).60 patients were divided into the study group and control group by minimum unbalance index method.The study group received 20 Hz rTMS treatment, and the control group received rTMS fake stimulation treatment.Treatment was performed 5 times a week for 8 weeks.Mini-Mental State Examination(MMSE), Montreal Cognitive Assessment(MoCA) and Alzheimer's Disease Assessment Scale-cognitive subscale(ADAS-cog) were evaluated before and after treatment.Results There was no significant difference among the swres of those scales before treatment between two groups(all P>0.05).There was statistical difference of the scores of those scales after treatment for 8 weeks between two groups(P<0.05).Conclusion High frequency (20 Hz) rTMS may help to improve the cognitive function of AD patients, and the safety is better.