中医辨证治疗脓毒症疗效观察

目的:观察中医辨证治疗对严重脓毒血症患者的治疗效果。方法:将符合脓毒血症诊断标准的106例患者随机分为两组,对照组50例,给予常规治疗;治疗组56例,在常规治疗基础上加用中医辨证治疗7天,观察两组患者治疗前后的体温(T)、心率(HR)、白细胞计数(WBC)、中性粒细胞率(N)、血小板计数(PLT),并检测炎症因子TNF、IL-6、IFN-γ,IL-4值的变化。结果:两组治疗后比较,治疗组患者的T、HR、WBC、N、PLT与对照组比较有显著性改善(P0.05)。炎症因子TNF、IL-6、IFN-γ,IL-4值与对照组比较有显著性降低(P0.05)。结论:中医辨证治疗可能通过调控机体炎症反应过程,较早地阻断了SIRS向MODS发展。临床上用于治疗严重脓毒血症具有良好的效果。

Clinical Effective Observation on Treating Sepsis in TCM Treatment

Objective:To observe the curative effect in severe sepsis patients treated according to syndrome differentiation of Traditional Chinese Medicine(TCM).Methods:106 severe sepsis patients were allocated in the control group(n=50)treated with conventional method of western medicine,and the TCM-treated group(n=56)treated according to syndrome differentiation of TCM based on the conventional western medicine.The body temperature(T),heart rate(HR),white blood cell count(WBC),neutrophil ratio,platelet count(PLT),serum tumor necrosis factor-α(TNF-α),Interleukin(IL)-4,IL-6 and IFN-γ were determined before treatment and 7 days after treatment.Results:After treatment,the T,HR,WBC,N and PLT in treatment group were significantly improved than those of control group(P<0.05).And at the same time,the TNF,IL-6,IFN-γ and IL-4 in treatment group were significantly lower than those of control group(P<0.05).Conclusion:TCM treatment based on syndrome differentiation may block the development of SIRS to MODS by controlling the process of early inflammatory response.It is effective on severe sepsis patients.