| 化瘀止痛方外用对骨转移癌疼痛大鼠脊髓背角的影响 |
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| 引用本文： | 邓博,贾立群,蔡大勇,谭煌英,高福云,潘琳.化瘀止痛方外用对骨转移癌疼痛大鼠脊髓背角的影响[J].中华中医药学刊,2012(5):972-973. |
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| 作者姓名： | 邓博 贾立群 蔡大勇 谭煌英 高福云 潘琳 |
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| 作者单位： | 中国医学科学院北京协和医学院药用植物研究所;中日友好医院 |
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| 基金项目： | 国家“十一五”科技支撑计划资助项目(2008BAI53B023) |
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| 摘 要： | 目的:研究化瘀止痛方外用对骨转移癌疼痛大鼠的镇痛作用及机制。方法:采用大鼠乳腺癌MRMT-1细胞,按Medhurst方法建立骨转移癌疼痛模型。以唑来膦酸为阳性对照,观察外用药对大鼠脊髓背角神经元原癌基因c-FOS蛋白表达、神经胶质细胞胶质细胞酸性蛋白(GFAP)表达的影响。结果:相对于假手术组,各手术组脊髓后角神经元c-FOS蛋白表达明显增高,GFAP染色阳性星形胶质细胞明显增生肥大。与模型组比较,脊髓背角c-FOS表达明显降低(P0.05),GFAP表达变化改善。结论:外用中药对骨转移癌疼痛模型有明显镇痛作用,作用机制与拮抗伤害感受器并且抑制痛觉在脊髓水平的放大有关。
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| 关 键 词： | 骨转移癌疼痛 外治法 中药 MRMT-1细胞 |
Influence of Formula for Resolving Stasis and Relieving Pain on Pinal Cord Dorsal Horn of Rats with Bone Cancer Pain |
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| DENG Bo,JIA Li-qun,CAI Da-yong,TAN Huang-ying,GAO Fu-yun,PAN Lin.Influence of Formula for Resolving Stasis and Relieving Pain on Pinal Cord Dorsal Horn of Rats with Bone Cancer Pain[J].Chinese Archives of Traditional Chinese Medicine,2012(5):972-973. |
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| Authors: | DENG Bo JIA Li-qun CAI Da-yong TAN Huang-ying GAO Fu-yun PAN Lin |
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| Institution: | 1.Institute of medical plant development,Chinese academy of medical science &Peking Union Medical College,Beijing 100193,China; 2.China-Japan Friendship Hospital,Beijing 100029,China) |
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| Abstract: | Objective: Evaluate the anti——nociceptive effects of herbal medicine extraction in a rat model of bone cancer pain.Methods:Following Medhurst’s method,a rat model of cancer-induced bone pain was established using the MRMT-1 cell line.The corresponding segments of the ipsilateral spinal cord were processed for c-fos staining and glial fibrillary acidic protein(GFAP)staining.Results:Compared to sham-operation group,c-fos and GFAP expression in the spinal cord dorsal horn of the model group was significantly increased.Compared to model group,treatment with herbal medicine extraction(ad us.ext.)significantly inhibited c-fos expression(P<0.05),GFAP expression was also attenuated.Conclusions:The herbal medicine extraction is an anti-nociceptive agent in a rat model of metastatic cancer pain. |
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| Keywords: | bone cancer pain external administration herbal medicine extraction tumor cell line MRMT-1 |
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