MMP-2与动脉粥样硬化、脑梗死的关系浅析

脑梗死(cerebral infarction,CI)是常见的脑血管疾病,严重影响人类的健康;动脉粥样硬化(atherosclerosis,AS)是脑梗死发生的一个重要因素,颈动脉粥样硬化斑块尤其是易损斑块的形成,是缺血性心脑血管病的共同基础;基质金属蛋白酶-2(MMP-2)可以对动脉粥样硬化斑块的纤维帽与基底膜产生裂解作用及参与血管内膜的炎性反应,其在血液中的病理性增高可影响动脉粥样硬化斑块的稳定性,是导致斑块破裂、引起脑梗死的关键因素之一,并对脑梗死的程度、预后有重要影响。

Study On the Relationship Among MMP-2,Atherosclerosis And Cerebral Infarction

Cerebral infarction is a common cerebrovascular disease,seriously affecting people’s health.Atherosclerosis is an important factor that causes cerebral infarction.Carotid atherosclerotic plaques especially vulnerable plaques form,is the common basis of ischemic cerebrovascular disease.Matrix metallo proteinases-2 can crack fibrous cap of atheromatous plaque and basement membrane,and participate in the lining of the blood vessels inflammatory reaction.The increase of MMP-2 content in the blood is one of the key factors that can affect the stability of the atherosclerotic plaque,and cause plaque fracture and cerebral infarction,and the degree of cerebral infarction prognosis has important influence.