岩柏草总黄酮对大鼠肝损伤保护作用的研究

目的:探讨卷柏对实验性肝损伤大鼠保护作用机理。方法:采用四氯化碳(CCl4)腹腔注射导致大鼠急性肝损伤的动物模型,用岩柏草总黄酮混悬液灌胃给药,并以水飞蓟宾葡甲胺组为实验对照。结果:岩柏草总黄酮能显著地降低CCl4所致大鼠血清中ALT、AST、NO、PGE2和肝组织中MDA的含量;并可使CCl4所致大鼠肝组织中降低的SOD活性升高,改善肝脏组织的病理损伤。结论:岩柏草对CCl4所致大鼠肝损伤具有保护作用,其作用机理可能与降酶、抗脂质过氧化反应、清除自由基、抑制NO过量成生,降低PGE2含量等有关。

Protective Effect of Total Flavonoids of Selaginella moellendorfii Hieron on Experimental Liver Injury in Mice

Objective:To explore the protective effect of selaginella moellendorfii hieron on experimental liver injury in mice.Method:Acute liver injury models were made by carbon tetrachloride(CCl4),and then were intragastric administered with selaginella moellendorfii hieron.Result:The change of the serum contents of ALT,AST,NO,PGE2,hepatic tissue SOD,MDA,and pathological tissue slices of liver were observed.The result showed that total flavonoids of selaginella moellendorfii hieron could significantly decrease the serum ALT,AST,NO,PGE2 of abnormally high levels induced by CCl4,decrease MDA and increase the activity of SOD of liver tissue,and ameliorate the pathological injure of liver.Conclusion:The protective mechanisms of total flavonoids on liver injury may be correlated to reducing the serum levels of ALT and AST,inhibiting lipid peroxide,cleaning free radical,restraining the excess production of NO and lowering PGE2.