| 豨莶草对小鼠全脑缺血再灌注模型的药效学观察 |
| |
| 引用本文： | 韩蕾,周晓辉,王维伟.豨莶草对小鼠全脑缺血再灌注模型的药效学观察[J].中华中医药学刊,2012(10):2287-2289. |
| |
| 作者姓名： | 韩蕾 周晓辉 王维伟 |
| |
| 作者单位： | 江苏建康职业学院药学系;中国药科大学临床药学教研室 |
| |
| 基金项目： | 中国药科大学引进人才启动基金资助项目(01211100) |
| |
| 摘 要： | 目的:探讨豨莶草抗小鼠实验性全脑脑缺血再灌注损伤作用。方法:通过夹闭双侧颈总动脉的方法制作小鼠全脑缺血再灌注模型,观察灌胃给予豨莶草14g生药/kg对脑组织Evans蓝含量、SOD及MDA水平的影响。结果:豨莶草可降低缺血再灌注后模型动物的脑组织Evans蓝含量,提高SOD活性,降低MDA水平。结论:豨莶草能增加脑缺血再灌注模型小鼠抗氧化酶的活性,改善脑血流,减轻血脑屏障的损伤,对脑缺血再灌注损伤具有一定的保护作用。
|
| 关 键 词： | 豨莶草 脑缺血再灌注 小鼠 抗氧化酶 |
Observation on Effect of Herba Siegesbeckiae on Antioxidase during Cerebral Ischemia-Reperfusion Injury in Mice |
| |
| HAN Lei,ZHOU Xiao-hui,WANG Wei-wei.Observation on Effect of Herba Siegesbeckiae on Antioxidase during Cerebral Ischemia-Reperfusion Injury in Mice[J].Chinese Archives of Traditional Chinese Medicine,2012(10):2287-2289. |
| |
| Authors: | HAN Lei ZHOU Xiao-hui WANG Wei-wei |
| |
| Institution: | 1.Jiangsu Jiankang Vocational College,Nanjing 211800,Jiangsu,China; 2.China Pharmaceutical University,Nanjing 211198,Jiangsu,China) |
| |
| Abstract: | Objective:To investigate the effect of Herba Siegesbeckiae(HS)on the antioxidase during cerebral ischemia-reperfusion injury in mice.Methods:The HS was repeated given orally in mice model of cerebral ischemia-reperfusion injury in the EB-treated group.The contents of Evans blue and antioxidase in the brain tissue were changed.Results:The cerebral blood flow in EB-treated group decreased after the ischemia-reperfusion injury.In the HS-treated group,the antioxidase activity increased,and the content of malondialodehyde decreased.Conclusion:HS may protect the brain from ischemia-reperfusion injury by increasing the activity of antioxidase,improving the cerebral blood flow,and alleviating the damage of blood-brain barrier. |
| |
| Keywords: | Herba Siegesbeckiae cerebral ischemia-reperfusion injury mice antioxidase |
| 本文献已被 CNKI 等数据库收录！ |
|
