中药五白散对308nm准分子激光诱导色素沉着动物模型的影响

目的:探讨中药五白散对308nm准分子激光诱导的色素沉着豚鼠模型的影响。方法:308nm准分子激光诱导色素沉着豚鼠模型。造模成功后,色素沉着区分为单纯基质乳膏组、2%氢醌组和中药五白散组,分别对应外涂于皮损区。外用治疗30天后,对各组的黑色素指数、黑素细胞、黑素颗粒及皮肤组织病理学检查观察药物的疗效和安全性。结果:五白散可降低黑色素指数水平,抑制黑素细胞活性,减少黑素生成,减轻UVB所致皮肤色素沉着的程度。结论:中药五白散对308nm准分子激光诱导豚鼠色素沉着有明显的改善作用,其机制可能是一定程度上抑制酪氨酸酶活性,减少黑素生成。

Influence of Wubai Powder on Pigmentation Animal Model induced by 308nm Excimer Laser

Objective:To observe the influence of Wubai Powder on pigmentation animal model induced by 308nm excimer laser.Methods:308nm excimer laser induced pigmentation animal model.After establishing the model,the areas of pigmentation were divided into 3 group:single matrix cream group,2% hydroquinone group and Wubai Powder group,and daubed them on corresponding lesions.After treamting for 30 days,the efficacy of the tested drug was evaluated comprehensively by measurements of melanin index,melanocyte,melanin as well as the histopathology of skin.Result:It was shown that the tested drug can decrease the level of melanin index,restrain the activity of melanocyte,reduce the generation of melanin and relieve pigmentation caused by UVB.Conclusion:Wubai Powder had obvious treatment function on 308nm excimer laser-induced pigmentation,its mechanism was to inhibit the activity of tyrosinase,which decreased melanin generation.