| 寒性药物对大鼠脑梗死的保护作用 |
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| 引用本文： | 韩蕾,张青娟,徐钦峰,周晓辉. 寒性药物对大鼠脑梗死的保护作用[J]. 中华中医药学刊, 2012, 0(3): 632-635 |
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| 作者姓名： | 韩蕾 张青娟 徐钦峰 周晓辉 |
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| 作者单位： | 江苏建康职业学院;中国药科大学临床药学教研室;辽宁中医药大学 |
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| 基金项目： | 中国药科大学引进人才启动基金资助项目(01211100) |
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| 摘 要： | 目的:通过线栓法造成大鼠局灶性脑梗死,观察寒性药物豨莶草提取物对大鼠脑梗死的保护作用。方法:将大鼠分为4组,分别为模型组,阳性药物尼莫地平12mg/kg组,假手术组,豨莶草提取物7g生药/kg给药组。灌胃给药,观察药物对大鼠大脑中动脉阻断模型脑梗死面积、行为学指标、血清SOD,MDA含量等指标变化的影响。结果:豨莶草提取物可减小模型动物梗死面积,对行为学指标有一定的降低趋势、血清SOD,MDA含量等指标有一定的影响,但不具有统计学差异。结论:豨莶草提取物对大鼠脑梗死可能具有一定的保护作用。
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| 关 键 词： | 豨莶草 大脑中动脉阻断 大鼠 保护作用 |
Protective Effect of Cold Medicine-Herba Siegesbeckiae Extraction on Rats of Cerebral Infraction |
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| Affiliation: | HAN Lei1,ZHANG Qing-juan2,XU Qin-feng3,ZHOU Xian-hui2(1.Jiangsu Professional College,Nanjing 210036,Jiangsu,China;2.China Pharmaceutical University,Nanjing 211169,Jiangsu,China; 3.Liaoning University of TCM,Shenyang 110847,Liaoning,China) |
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| Abstract: | Objective: To discuss the protective effect of Herba Siegesbeckiae extraction on the rats of cerebral infraction.Methods:24 rats were randomly divided into 4 groups,that is sham-operation group,model group,Herba Siegesbeckiae extraction group and nimodipine control group.MCAO model was induced by a middle cerebral artery occlusion,preparation of 7g/kg Herba Siegesbeckiae extraction was given orally,and infarct area,ethological index,SOD and MDA in serum were observed.Results:Comparing with the model group,infarct area and ethological index in the Herba Siegesbeckiae extraction group tended to decrease,whereas there were no remarkable changes of SOD and MDA.Conclusion:7g/kg of Herba Siegesbeckiae orally has a protective tendency on MCAO rats. |
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| Keywords: | Herba Siegesbeckiae MCAO rat protective function |
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