平性活血化瘀药对正常大鼠血流动力学的影响

目的:研究10味平性药、5味寒性药、5味温性药对大鼠血流动力学的作用。方法:大鼠随机分为空白对照组、平性药高、低剂量组,温性药对照组、寒性药对照组连续灌胃给药14天。末次药后各鼠全身肝素化2h,测定各鼠肝素化5min、1h、2h的心率(HR)、动脉收缩压(SP)、动脉平均压(AP)、左心室收缩压(LVSP)、左心室平均压(LVAP)、左心室内压最大下降速率(-dp/dtm)等指标。结果:平性药桃仁、苏木、血竭、蒲黄及寒性药大黄可使心肌收缩和舒张功能加强;平性药三棱、合欢皮、王不留行及寒性药益母草、丹参可使心肌收缩力加强;平性药肿节风可使心肌舒张功能加强;温性药红花、三七、川芎、当归可使心肌收缩和舒张功能减弱;温性药桂枝可提高心率,升高动脉血压,心肌收缩功能加强,舒张功能减弱。结论:平性药桃仁、苏木、血竭、三棱、王不留行、蒲黄、肿节风、寒性药益母草、大黄、丹参可改善心脏功能,温性药红花、三七、川芎、当归可能会加重心脏负担。

Study on Herbs with Neutral Nature and Blood Circulation Promoting and Blood Stasis Removing Action on the Hemodynamic Indexes of Rats

Objective:To study the effect of 10 herbs with neutral nature,5 herbs with cold nature,and 5 herbs with hot nature on the hemodynamic indexes of rats.Methods:Rats were randomly divided into different groups,including normal control group,high dosage neutral nature herbs group,low dosage neutral nature herbs group,cold nature herbs control group,and hot nature herbs control group.The above rats were given herbs decoction by continuous oral administration for 14 days.After last administration,rats were wholly heparinized for 2 hours,the indexes including HR,SP,AP,LVSP,LVAP,and DP/DTM at 5min,1h,2h after heparinization were tested.Result:The decoction of neutral nature herbs,such as semen persicae,lignum sappan,sanguis draconis,Pollen Typhae,and cold nature herbs,rhubarb root,could improve the function of cardiac muscle.The decoction of neutral nature herbs,such as rhizoma sparganii,cortex albiziae,semen vaccariae,and cold nature herbs,Herba leonuri,radix salviae miltiorrhizae,could strengthen cardiac contractility.The decoction of neutral nature herb,herba sarcandrae,could strengthen cardiac diastolic function.The decoction of hot nature herb,flos carthami,radix notoginseng,rhizoma chuanxiong,and radix angelicae sinensis,could decrease myocardial systolic and diastolic function.The decoction of hot nature herb,ramulus cinnamomi,could increase heart rate,elevate arterial blood pressure,enhance myocardial contractile function and reduce diastolic function.Conclusion:The neutral nature herbs including semen persicae,lignum sappan,sanguis draconis,rhizoma sparganii,semen vaccariae,pollen typhae,herba sarcandrae,and the cold nature herbs including herba leonuri,rhubarb root,radix salviae miltiorrhizae,could improve the cardiac function.The hot nature herbs including flos carthami,radix notoginseng,rhizoma chuanxiong,radix angelicae sinensis could burden on the heart.