益气化瘀汤对早期糖尿病肾病细胞因子水平干预的研究

目的:探讨益气化瘀汤对早期糖尿病肾病(DN)血细胞因子的影响。方法:将105例早期糖尿病肾病随机分为对照组(50例)与观察组(55例)。对照组用洛汀新片:10mg/次,1次/日,口服;观察组在对照组基础上加用益气化瘀汤每天1剂,8周为1疗程。治疗前后检测血白介素(IL-8)、IL-18、肿瘤生长因子a(TNF-a)水平。并附50例健康对照组。结果:两组治疗前炎性细胞因子比较差异无统计学意义(P0.05),但明显高于健康组(P0.01);观察组自身治疗前后细胞因子水平比较均明显下降(P0.01);治疗后两组比较,差异有统计学意义(P0.01)。结论:IL-8、IL-18、TNF-a与糖尿病肾病的发生发展相关,益气化瘀汤可能在抑制早期糖尿病肾病发展过程中起着积极的作用。

Study on Intervention Effect of Yiqi Huayu Decoction on the Cell Factor Levels in Early Diabetic Nephropathy

Objective:To explore the effect of Yiqi Huayu decoction on the blood cell factors in early diabetic nephropathy(EDN).Method:105 patients of END were randomly divided into control group(50 cases)and treatment group(55 cases).The control group was treated with lotensin of 10mg/time,once a day by oral intake;on the basis of control group,the treatment group was added with the Yiqi Huayu decoction,1 agent a day,8 weeks was a period of treatment.Interleukin(IL-8),IL-18 and tumor growth factor α(TNF-α)levels in blood were tested before and after the treatment.50 cases of health control were also included.Result:Before treatment,there was no significant statistical difference of inflammatory cells factor between two groups(P>0.05),however,both were significantly higher than that in health group(P<0.01).The cell factor levels declined significantly before and after the treatment in treatment group(P<0.01).After treatment,there was significant statistical difference between two groups(P<0.01).Conclusion:IL-8,IL-18 and TNF-α were associated with the development of diabetic nephropathy,and Yiqi Huayu decoction may play a positive role to inhibit the development process in early diabetic nephropathy.