| 氯沙坦对急性心肌梗死大鼠左室非梗死区P38MAPK表达的影响 |
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| 引用本文： | 张进,佘强. 氯沙坦对急性心肌梗死大鼠左室非梗死区P38MAPK表达的影响[J]. 北方药学, 2012, 0(10): 60-61 |
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| 作者姓名： | 张进 佘强 |
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| 作者单位： | 重庆医科大学第二附属医院心内科 |
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| 基金项目： | 2010重庆医科大学校级重点项目(XBZD.201010) |
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| 摘 要： | 目的:研究氯沙坦(Losartan)干预对急性心肌梗死(AMI)大鼠左室非梗死区(LVNIZ)P38MAPK、p-P38MAPK表达的影响。方法:将40只雄性Wistar心肌梗死大鼠随机分为AMI组(n=30)及Losartan组(n=10)。另设空白对照组(Sham)。Western-blot印记检测LVNIZP38、p-P38的表达。结果:AMI后28天组P38、p-P38的表达水平达到高峰(P<0.01vsSham);与AMI后28天组相比,氯沙坦组p-P38的表达显著降低(P<0.01)。结论:心肌梗死后LVNIZP38MAPK信号被激活,氯沙坦改善心室重构的机制可能是阻断了P38MAPK信号通路。
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| 关 键 词： | 心肌梗死 丝裂原活化蛋白激酶(P38MAPK) |
The effects of losartan on P38 MAPK after myocardial infarction in the rat |
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| Zhang Jin She Qiang. The effects of losartan on P38 MAPK after myocardial infarction in the rat[J]. BEIFANG YAOXUE, 2012, 0(10): 60-61 |
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| Authors: | Zhang Jin She Qiang |
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| Affiliation: | Zhang Jin She Qiang*(Department of Cardiology, the Second Affiliated Hospital of Chong Qing University of medical science, Chongqing 400016,China) |
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| Abstract: | Objective:To study the effect of losartan on the expression P38、p-P38 in non-infarction zone of left ventricule (LVNIZ) in AMI rat. Methods: The 40 surviving AMI male Wistar rats were randomly divided into 2 groups: AMI group (n=30) and losartan treated group(n=10).Western-blot analyzed the expression of P38、p-P38 protein in LVNIZ. Results: Compared with Sham rats; the expression of P38、p-P38 protein in LVNIZ peaked at 28th day after MI group(P<0.01);p-P38 protein were decreased in losartan group compared with 28th day after MI group(P<0.01).Conclusion: P38MAPK signaling was activated in LVNIZ, losartan block the signal conduction of P38MAPK and improved the cardiac remodeling. |
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| Keywords: | Myocardial infarction P38MAPK (mitogen -activated protein kinase) |
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