| 白血病预后影响因素的临床研究 |
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| 引用本文： | 程枫,陈苏宁. 白血病预后影响因素的临床研究[J]. 北方药学, 2012, 9(7): 39-40 |
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| 作者姓名： | 程枫 陈苏宁 |
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| 作者单位： | 江苏省苏州大学附属第一医院,苏州,215006;江苏省苏州大学附属第一医院,苏州,215006 |
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| 摘 要： | 目的:探讨影响白血病预后的相关因素。方法:①采用流式细胞仪(FCM)对入选急性白血病进行免疫分型。②初诊的急性髓系白血病(AML)分别予CAG,HCAG,DA(3+7)标准方案化疗,急性淋巴细胞性白血病(ALL)予DOP或DOLP方案化疗,急性杂合性白血病(ABL)予DOAP方案化疗。结果:①AML患者常见表达抗原依次为:CD13>CD33>CD117>CD38>HLA-DR>CD34>CD64>CD14>CD56>CD7。②B系ALL主要表达抗原为CD10,CD19及非特异性祖系抗原HLA-DR。③T系ALL主要表达抗原为CD7,CD5和髓系CD13以及非特异性祖系抗原CD38。④My+ALL以及Ly+AML预后较差。结论:白血病免疫分型为制订方案和判断预后提供了重要依据。
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| 关 键 词： | 白血病 影响因素 临床研究 |
Clinical research of leukemia prognostic factors |
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| Cheng Feng Chen Suning. Clinical research of leukemia prognostic factors[J]. BEIFANG YAOXUE, 2012, 9(7): 39-40 |
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| Authors: | Cheng Feng Chen Suning |
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| Affiliation: | Cheng Feng Chen Suning(First Affiliated Hospital of Suzhou University SuZhou 215006,China) |
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| Abstract: | Objective:To analyse the direction significance of immunological classificiation in estimating prognosis. Method:①Immunophenotypes were examined by FCM in 32 acute leukemia.②Patients began to receive chemical therapy after diagnosing. We cured myeloblastic(AML) with the projects named as CAG,HCAG,DA,etc,and cured lymphoblastic(ALL)wih DOP,POLP,etc,and cured biphenotypic leukemia(ABL) with DOAP.Results:①Myeloblastic agents were often expressed as follows:CD13,CD33,CD117,CD38,HLA-DR,CD34,CD64,CD14,CD56,CD7 in order of decreasing level.②CD10,CD19,HLA-DR agents were highly expressed in B lymphoblastic.③CD7,CD5,CD13,CD38 agents were highly expressed in T lymphoblastic.④My+ALL and Ly+AML had a poor prognosis.Conclusion:Immunological classificiation has important value in therapy and prognosis of AL. |
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| Keywords: | Acute Leukemia IInfluencing factorsPrognosisC linical research |
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