| 反相高效液相色谱法测定氟哌啶醇注射液含量 |
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| 引用本文： | 王巍,余翔,周祥敏. 反相高效液相色谱法测定氟哌啶醇注射液含量[J]. 北方药学, 2012, 9(9): 3-4 |
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| 作者姓名： | 王巍 余翔 周祥敏 |
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| 作者单位： | 重庆市涪陵药品检验所,重庆,408000;重庆市食品药品检验所,重庆,401121 |
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| 摘 要： | 目的:建立反相高效液相色谱法测定氟哌啶醇注射液含量的方法。方法:色谱柱为AgilentEclipseXDBC18(250mm×4.6mm,5μm),流动相为0.1mol·L-1磷酸二氢钾-甲醇(40∶60)(用磷酸调节pH值至3.5);流速1.0mL·min-1;检测波长248nm;柱温25℃。结果:氟哌啶醇进样量在0.1069～1.0690μg范围内与峰面积响应值呈良好的线性关系,r=0.9999;平均回收率为99.16%,RSD为0.66%(n=6)。结论:本方法操作简便,结果准确,灵敏度高,重现性好,可作为氟哌啶醇注射液质量控制的方法。
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| 关 键 词： | 反相高效液相色谱法 氟哌啶醇注射液 含量测定 |
Determination of Haloperidol Injection by RP-HPLC |
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| Wang Wei,Yu Xiang,Zhou Xiangmin. Determination of Haloperidol Injection by RP-HPLC[J]. BEIFANG YAOXUE, 2012, 9(9): 3-4 |
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| Authors: | Wang Wei Yu Xiang Zhou Xiangmin |
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| Affiliation: | 1.Fuling Institute for Drug Control,Fuling,Chongqing,China 408000;2.Chongqing Institute for Food and Drug Control,Chongqing,China 401121) |
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| Abstract: | Objective:To establish a quantitative method for Haloperidol Injection by RP-HPLC. Methods:Agilent Eclipse XDB C18 column（250mm×4.6mm,5μm）was used. The 0.1mol·L-1 potassium dihydrogen phosphate solution - methanol（40∶60）（adjusting pH to 3.5 with phosphoric acid）solution was used as the mobile phase. The flow rate was 1.0mL·min-1 . The detection wavelength was set at 248nm. Column temperature:25℃ .Results:The linear range of Haloperidol was 0.1069～1.0690μg and the correlation coefficient was 0.9999. The average recovery rate was 99.16% with RSD 0.66%（n =6）.Conclusion:The method is convenient and accurate, reproducible and sensitive,which can be used to control the quality of Haloperidol Injection. |
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| Keywords: | RP-HPLC Haloperidol Injection Content determination |
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