| 孕妇外周血中游离胎儿核酸的研究进展 |
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| 引用本文： | 贾颐舫,吴爱华,张爱东. 孕妇外周血中游离胎儿核酸的研究进展[J]. 中国妇幼健康研究, 2004, 15(5): 285-287 |
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| 作者姓名： | 贾颐舫 吴爱华 张爱东 |
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| 作者单位： | 山东省计划生育科研所优生技术重点实验室,山东,济南,250002;山东省计划生育科研所优生技术重点实验室,山东,济南,250002;山东省计划生育科研所优生技术重点实验室,山东,济南,250002 |
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| 摘 要： | 非创伤性产前诊断一直是人类遗传学发展的长期目标 ,从非细胞成分中如母血浆和血清中检测胎儿DNA为非创伤性产前诊断的开展提供了可能。实时定量PCR分析技术的发展 ,使母血浆和血清中胎儿DNA检测的敏感性和特异性接近 10 0 % ,同时胎儿核酸领域的研究也扩展到了母血浆中胎儿RNA和胎儿表遗传标记物的检测
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| 关 键 词： | 胎儿DNA 胎儿RNA 胎儿表遗传标记物 非创伤性产前诊断 |
| 文章编号： | 1008-2514(2004)05-0285-03 |
| 修稿时间： | 2004-04-22 |
Progress in study on fetal cell-free nucleic acid in maternal peripheral blood |
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| JIA Yi-fang,WU Ai-hua,ZHANG Ai-dong. Progress in study on fetal cell-free nucleic acid in maternal peripheral blood[J]. Chinese Journal of Maternal and Child Health Research, 2004, 15(5): 285-287 |
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| Authors: | JIA Yi-fang WU Ai-hua ZHANG Ai-dong |
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| Abstract: | Noninvasive prenatal diagnosis is a long-sighted goal of human genetics. The fact that fetal DNA can be found in noncellular fractions, i.e.plasma and serum of maternal peripheral blood provides a possibility to perform noninvasive prenatal diagnosis .The subsequent development of real-time quantitative PCR technique has allowed close to 100% of sensitivity and specificity for fetal DNA detection in maternal plasma/serum. Meanwhile, this technique also has developed a detection for fetal RNA and fetal epigenetic markers from maternal plasma. |
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| Keywords: | fetal DNA fetal RNA fetal epigenetic marker noninvasive prenatal diagnosis |
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