| 蛋白质对半饥饿大鼠肠黏膜屏障的保护作用 |
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| 引用本文： | 于晓明,王永辉,李培兵,金宏. 蛋白质对半饥饿大鼠肠黏膜屏障的保护作用[J]. 肠外与肠内营养, 2008, 15(6): 329-331,334 |
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| 作者姓名： | 于晓明 王永辉 李培兵 金宏 |
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| 作者单位： | 1. 解放军三○一医院营养科,北京,100853
2. 军事医学科学院卫生学环境医学研究所,天津,300050 |
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| 摘 要： | 目的:研究大鼠半饥饿状态下肠黏膜屏障的变化与补充蛋白质对其的保护作用. 方法:将48只大鼠随机分为正常对照组、50%正常饲料组、50%正常饲料+蛋白质组.2周后处死大鼠,测定小肠黏膜超氧化物歧化酶(SOD)活性、丙二醛(MDA)、DNA含量,肠系膜淋巴结(MLN)细菌移位率和血清D.木糖水平等. 结果:50%正常饲料+蛋白质组大鼠小肠黏膜DNA含量、SOD活性明显高于50%正常饲料组(P<0.05);血清D-木糖水平和MDA含量明显低于50%正常饲料组(P<0.05).结论:大鼠半饥饿状态下,增加饲料中蛋白质比例,对半饥饿大鼠肠黏膜具有一定的保护作用.
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| 关 键 词： | 饥饿 肠黏膜屏障 蛋白质饮食 |
The protective effect of supplementation of protein diet on intestinal barrier in semi-starvation rats |
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| YU Xiao-ming,WANG Yong-hui,LI Pei-bing,JIN Hong. The protective effect of supplementation of protein diet on intestinal barrier in semi-starvation rats[J]. Parenteral & Enteral Nutrition, 2008, 15(6): 329-331,334 |
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| Authors: | YU Xiao-ming WANG Yong-hui LI Pei-bing JIN Hong |
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| Affiliation: | YU Xiao-ming1,WANG Yong-hui2,LI Pei-bing2,JIN Hong2(1.Department of Nutrition,General Hospital of Chinese PLA,Beijing 100853,China,2.Institute of Hygiene , Environmental Medicine,Academy of Military Medical Sciences,Tianjin 300050,China) |
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| Abstract: | Objective: To study the effects of supplement of protein diet on intestinal tract in semi-starvation rats. Methods: Forty-eight male Wister rats were divided into control , 50% intake, 50% intake with supplementation of protein diet groups. SOD, MDA and DNA were determined in intestinal mucosa. Bacterial translocation rate in mesenteric lymphatic nodes(MLN) and xylose absorption were examined. Results: The content of DNA in 50% intake with supplementation of protein diet group was higher than that in contro... |
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| Keywords: | Starvation Intestinal mucosal barrier Protein diet |
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