Fatty acid profile of the erythrocyte membrane preceding development of Type 2 diabetes mellitus |
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| Authors: | Krachler Benno Norberg Margareta Eriksson Jan W Hallmans Göran Johansson Ingegerd Vessby Bengt Weinehall Lars Lindahl Bernt |
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| Institution: | 1. Division of Human Nutrition, Department of Food, Environmental and Nutritional Sciences, Università degli Studi di Milano, Milan, Italy;2. Department of Public Health and Pediatric Sciences, Università degli Studi di Torino, Turin, Italy;1. Division of Gastroenterology and Hepatology, University of Michigan School of Medicine, 1150 W. Medical Center Drive, 6520 MSRB1, Ann Arbor, Michigan, United States;2. Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, United States;3. Division of Epidemiology, Vanderbilt University School of Medicine, United States;4. Geriatrics Research, Education and Clinical Center (GRECC), Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN, United States;5. Division of Gastroenterology, Vanderbilt University School of Medicine, United States;6. Department of Pathology, Microbiology and Immunology, Vanderbilt University, United States;7. Division of Clinical Pharmacology, Vanderbilt University School of Medicine, United States;8. Division of General Internal Medicine and Public Health, Vanderbilt University Medical Center, United States |
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| Abstract: | Background and aimsThe respective roles of dietary fatty acids in the pathogenesis of diabetes are as yet unclear. Erythrocyte membrane fatty acid (EMFA) composition may provide an estimate of dietary fatty acid intake. This study investigates the relation between EMFA composition and development of Type 2 diabetes mellitus.Methods and resultsIn a nested case-referent design we studied 159 individuals tested as non-diabetic at baseline who after a mean observation time of 5.4 ± 2.6 years were diagnosed with Type 2 diabetes mellitus and 291 sex- and age-matched referents. Higher proportions of pentadecanoic acid (15:0) and heptadecanoic acid (17:0) were associated with a lower risk of diabetes. In accordance with earlier findings, higher proportions of palmitoleic (16:1 n-7), dihomo-γ-linolenic (20:3 n-6) and adrenic (22:4 n-6) acids were associated with increased risk, whereas linoleic (18:2 n-6) and clupanodonic (22:5 n-3) acids were inversely associated with diabetes. After adjustment for BMI, HbA1c, alcohol intake, smoking and physical activity the only significant predictors were 15:0 and 17:0 as protective factors and 22:4 n6 as risk factor.ConclusionIn accordance with previous studies, our results indicate that EMFA-patterns predict development of Type 2 diabetes mellitus. The inverse association with two saturated fatty acids, previously shown to reflect consumption of dairy products, is a new finding. |
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