Reduced plasma c-AMP levels in children with atopic dermatitis |
| |
| Authors: | Damiano Carmelo Salpietro Francesco Naccari lsabella Polimeni Cristina Pellegrino |
| |
| Affiliation: | Chair of Pediatric Therapy. Institute of Medicine Preventive and Social Pediatrics;Chair of Veterinary Pharmacology, Department of Medicine and Veterinary Pharmacology;Fellowship - University of Messina (Italy) |
| |
| Abstract: | Plasma levels of cAMP and serum concentrations of IgE have been determined in children with acute atopic dermatitis (AD) and in a healthy control group, to illuminate the pathophysiological mechanisms that cause AD.
There were significantly lower plasma levels of cAMP (P < 0,001) and significantly higher levels of serum IgE (P < 0.004) in children with AD, in comparison with a healthy control group. It is possible that defective control of c-AMP levels could contribute to the immunopathogenesis of AD and monitoring levels may be of value in the clinical evaluation of the disease. |
| |
| Keywords: | Plasma levels c-AMP atopic dermatitis children. |
|
