星状神经节阻滞对乳腺癌围手术期体液免疫的影响

目的 观察星状神经节阻滞(SGB)对乳腺癌患者围手术期体液免疫的影响.方法 选择乳腺癌改良根治术女性患者80例,随机分为对照组40例,干预组40例.观察采用星状神经节阻滞干预前(T1)、干预后(T2)和术毕30min(T3)时IgG、IgA、IgM的变化并与时照组进行对比.结果 与T1比较,T2、T3时间点2组IgG、IgA、IgM均有不同程度下降(P<0.05,P<0.01).干预组与对照组比较T3时间点IgG(11.8±2.2)g/L与(9.5±1.5)g/L,t=5.4630,P=0.0041]、IgA(1.9±0.3)g/L与(1.7±0.4)g/L,t=2.5298,P=0.0134]差异均有统计学意义;干预组与对照组比较T2时间点IgM(2.5±0.8)g/L与(2.1±0.6)g/L,t=2.8276,P=0.0072]、T3(2.1±0.5)g/L与(1.6±0.5)g/L,t=4.4721,P=0.0000]差异均有统计学意义.结论 术前星状神经节阻滞可减轻乳腺癌改良根治术患者体液免疫的抑制程度.

The effect of stellate ganglion block on humoral immunity at perioperative period in patients with breastcancer

Objective To observe the effects of stellate ganglion block (SGB) on humoral immunity func-tion in patients who received modified radical mastectory (MRM). Methods Eigty female patients were randomly divided into control group(group Ⅰ ,n =40) and intervention group (group Ⅱ,n =40). Blood samples were taken pre-intervention (T1), after intervention ( T2 ) and 30 rain after operation ( T3 ) for the determination of lgG, IgA, IgM. Results Compared with T1, IgG, IgA, IgM at T2 and T3 in two groups were lowered, IgG ( 11.8±2.2 ) g/L vs (9.5 + 1.5) g/L,t = 5. 4630,P =0.0041 ] and IgA (1.9±0.3)g/L vs (1.7±0.4) g/L,t =2. 5298,P = 0.0134 ] at T3 in group Ⅱ were significantly different as compared with that of group Ⅰ ; IgM at T2 (2.5±0.8 ) g/L vs (2.1±0.6)g/L,t =2.8276,P=0.0072] and T3 (2.1±0.5)g/L vs (1.6±0.5)g/L,t =4.4721,P = 0.0000 ] was significantly different between the two groups. Conclusions Preoperative-SGB can improve the inhibi-tion degree of humoral immunity caused by modified radical mastectory.