| TIE2受体基因在野百合碱诱导的肺动脉高压中的表达 |
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| 引用本文： | 杨春光,李霞辉.TIE2受体基因在野百合碱诱导的肺动脉高压中的表达[J].中国医药导报,2010,7(30):12-13,23. |
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| 作者姓名： | 杨春光 李霞辉 |
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| 作者单位： | 大连大学医学院,辽宁大连,116622 |
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| 基金项目： | 辽宁省教育厅高校科研计划项目 |
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| 摘 要： | 目的：探讨TIE2受体蛋白在野百合碱诱导的肺动脉高压中的作用。方法：应用野百合碱诱导的慢性肺动脉高压大鼠模型,免疫组化观察肺动脉构型重建及细胞凋亡,应用RT-PCR技术检测大鼠肺动脉TIE2mRNA表达。结果：野百合碱大鼠肺动脉压明显升高,免疫组化观察到肺血管重构及内皮细胞层Caspase-3蛋白表达,野百合碱诱导的肺动脉高压大鼠肺血管TIE2mRNA表达明显减少。结论：在野百合碱诱导的肺动脉高压大鼠模型中,肺血管重构,内皮细胞损伤凋亡可能与肺血管TIE2受体表达降低有关。
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| 关 键 词： | 肺动脉高压 TIE2 基因表达 |
Expression of TIE2 gene in monocrotaline-induced pulmonary hypertension |
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| YANG Chunguang,LI Xiahui.Expression of TIE2 gene in monocrotaline-induced pulmonary hypertension[J].China Medical Herald,2010,7(30):12-13,23. |
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| Authors: | YANG Chunguang LI Xiahui |
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| Institution: | (Medical College of Dalian University,Dalian 116622,China) |
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| Abstract: | Objective：To investigate the effect of TIE2 gene in monocrotaline（MCT）-induced pulmonary hypertension.Methods：MCT-treated rats were used as a model for chronic PHT.The remodeling and cell apoptosis of pulmonary arteries（PAs） were analyzed by immunohistochemical method.RT-PCR was performed to identify the expression of TIE2 mRNA in rat PAs.Results：The pulmonary hypertension was established in MCT rats.The remodeling and protein expression of Caspase-3 were observed in PAs.A lower level of TIE2 mRNA expression was detected in PAs from MCT rats.Conclusion：The lower level of TIE2 mRNA expression might contribute to the remodeling and endothelial cell apoptosis of PAs in MCT-induced pulmonary hypertension. |
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| Keywords: | TIE2 |
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