Chemopreventive effect of dietary polyphenols in colorectal cancer cell lines |
| |
Authors: | Joã o R. Araú joPedro Gonç alves,Fá tima Martel |
| |
Affiliation: | Department of Biochemistry (U38-FCT), Faculty of Medicine of Porto, University of Porto, 4200-319 Porto, Portugal |
| |
Abstract: | Colorectal cancer (CRC) is the second most fatal and the third most diagnosed type of cancer worldwide. Despite having multifactorial causes, most CRC cases are mainly determined by dietary factors. In recent years, a large number of studies have attributed a protective effect to polyphenols and foods containing these compounds (fruits and vegetables) against CRC. Indeed, polyphenols have been reported to interfere with cancer initiation, promotion, and progression, acting as chemopreventive agents. The aim of this review is to summarize the main chemopreventive properties of some polyphenols (quercetin, rutin, myricetin, chrysin, epigallocatechin-3-gallate, epicatechin, catechin, resveratrol, and xanthohumol) against CRC, observed in cell culture models. From the data reviewed in this article, it can be concluded that these compounds inhibit cell growth, by inducing cell cycle arrest and/or apoptosis; inhibit proliferation, angiogenesis, and/or metastasis; and exhibit anti-inflammatory and/or antioxidant effects. In turn, these effects involve multiple molecular and biochemical mechanisms of action, which are still not completely characterized. Thus, caution is mandatory when attempting to extrapolate the observations obtained in CRC cell line studies to humans. |
| |
Keywords: | BT, butyrate CDK, cyclin-dependent kinase Cox, cyclooxygenase CRC, colorectal cancer CYP, cytochrome P450 EGCG, epigallocatechin-3-gallate EGFR, epidermal growth factor receptor ER, estrogen receptors ERK, extracellular signal-regulated kinase FHC, fetal human cell IGF, insulin-like growth factor iNOS, inducible nitric oxide synthase MAPK, mitogen-activated protein kinases NF-κB, nuclear factor κ B PPAR, peroxisome proliferator-activated receptors pRb, phosphorylated retinoblastoma TNF, tumor necrosis factor VEGF, vascular endothelial growth factor |
本文献已被 ScienceDirect 等数据库收录! |
|