|
|||||
|
|
Novel approaches to expanding the lung donor pool: donation after cardiac death and ex vivo conditioning |
|
| Authors: | Cypel Marcelo Yeung Jonathan C Keshavjee Shaf |
| Affiliation: | a Division Thoracic Surgery, Toronto Lung Transplant Program, Toronto General Hospital, University of Toronto, 200 Elizabeth Street, 9n969, Toronto, M5G 2C4, Canada b Latner Thoracic Surgery Laboratories, University of Toronto, 101 College Street, 2-815, Toronto, ON M5G 1L7, Canada c Division of Thoracic Surgery and Institute of Biomaterials and Biomedical Engineering, Toronto Lung Transplant Program, Latner Thoracic Research Laboratories, University of Toronto, 190 Elizabeth Street, RFE1-408, Toronto, M5G 2C4, Canada |
| Abstract: | Two novel approaches have been developed to potentially increase the availability of donor lungs for lung transplantation. In the first approach, lungs from donation after cardiac death (DCD) donors are used to increase the quantity of organ donors. In the second approach, a newly developed normothermic ex vivo lung perfusion (EVLP) technique is used as a means of reassessing the adequacy of lung function from DCD and from high-risk brain death donors prior to transplantation. This EVLP technique can also act as a platform for the delivery of novel therapies to repair injured organs ex vivo. |
| Keywords: | Lung transplantation Lung donation after cardiac death Ex vivo lung perfusion Pharmacologic/molecular intervention |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |