IGF—I和Bcl-2蛋白在多囊卵巢综合征胰岛素抵抗患者子宫内膜中的表达

目的通过对子宫内膜中胰岛素样生长因子-I（insulin—like growth factor—I，IGF—I）和Bcl-2基因蛋白表达的研究，探讨多囊卵巢综合征（PCOS）患者胰岛素抵抗对子宫内膜增生的作用机制。方法采用免疫组织化学ABC法检测92例PCOS胰岛素抵抗患者子宫内膜中IGF-1及Bcl-2的表达。结果PCOS体胰岛素抵抗患者子宫内膜中IGF-I表达量（203．54±18．29）较非胰岛素抵抗组的表达量（187．22±15．46）明显升高，差异有统计学意义（P〈O．001）；胰岛素抵抗组Bcl-2的表达量（200．94±15．43）与非胰岛素抵抗组（188．69±18．72）比较，差异有统计学意义（P〈O．01）；IGF—I与Bcl-2在子宫内膜中的表达呈正相关关系（r=0．42，P〈0．001）。结论PCOS胰岛素抵抗患者子宫内膜增生的发病可能与IGF—I及Bcl-2蛋白的表达有关。

Expression of protein IGF-I and Bcl-2 in endometrium in PCOS patients with insulin resistance

Objective To investigate the relationship between the expression of insulin- like growth factor- I （IGF- I） and Bcl - 2 in PCOS patients with or without insulin resistance. Methods 92 PCOS patients with or without insulin resistance underwent endometrium biopsies. The expression of IGF- I and Bcl - 2 were determined immunohistochemically. Results The expression of IGF - 1 protein in PCOS patients with insulin resistance （203. 54± 18. 29） was significantly higher than that in the PCOS patients without insulin resistance （187. 22±15. 46, P〈0. 001）; The expression of Bcl - 2 protein in PCOS patients with insulin resistance was 200. 94±15. 43 and 188. 69± 18. 72 in non - insulin resistance group. There was significantly difference between the groups （P〈O. 01）. A positive corre- lation was observed between the expression of IGF- I and Bcl - 2 （r=0. 42, P〈0. 001）. Conclusion The high incidence of hyperplasia in PCOS patients with insulin resistance may be correlated with IGF- I and Bcl- 2.