Impact of polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls on human and environmental health, with special emphasis on application of the toxic equivalency factor concept. |
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| Authors: | U G Ahlborg A Brouwer M A Fingerhut J L Jacobson S W Jacobson S W Kennedy A A Kettrup J H Koeman H Poiger C Rappe |
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| Affiliation: | Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden. |
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| Abstract: | A scientific evaluation was made of the mechanisms of action of polychlorinated dibenzo-p-dioxins, dibenzofurans and biphenyls. Distinction is made between the aryl-hydrocarbon (Ah) receptor-mediated and non-Ah receptor-mediated toxic responses. Special attention is paid to the applicability of the toxic equivalency factor (TEF) concept. |
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