| 纳米多孔二氧化硅作为药物载体的研究进展 |
| |
| 引用本文： | 胡延臣,王彦竹,王思玲. 纳米多孔二氧化硅作为药物载体的研究进展[J]. 沈阳药科大学学报, 2010, 27(12): 961-967 |
| |
| 作者姓名： | 胡延臣 王彦竹 王思玲 |
| |
| 作者单位： | 沈阳药科大学 药学院，辽宁 沈阳 110016 |
| |
| 基金项目： | 国家重大基础研究计划项目(2009CB930300); 国家自然科学基金项目(81072605) |
| |
| 摘 要： | 目的介绍几种纳米多孔二氧化硅作为药物载体的应用及最新发展动态。方法以国内外有代表性的文献资料31篇为依据,对介孔二氧化硅、二氧化硅气凝胶、微粉硅胶等几种多孔二氧化硅药物载体的结构特性、应用及发展动态进行分析、整理和归纳。结果纳米多孔二氧化硅作为药物载体,借助于其纳米孔道结构、形貌或孔道的控制及表面功能化修饰,可以实现药物的速释、缓释及pH或温度敏感释放。结论纳米多孔二氧化硅作为药物载体具有广阔的应用前景。
|
| 关 键 词： | 介孔二氧化硅 二氧化硅气凝胶 药物载体 |
| 收稿时间： | 2010-08-30 |
Recent progress of nano-porous silica as drug carrier |
| |
| HU Yan-chen,WANG Yan-zhu,WANG Si-ling. Recent progress of nano-porous silica as drug carrier[J]. Journal of Shenyang Pharmaceutical University, 2010, 27(12): 961-967 |
| |
| Authors: | HU Yan-chen WANG Yan-zhu WANG Si-ling |
| |
| Affiliation: | School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China |
| |
| Abstract: | Objective To review the application and recent progress of nano-porous silica for drug delivery. Methods Based on the representative references, the structure and application of several nano-porous silica materials, such as Aerosil, mesoporous silica and silica aerogel, were summarized. Results Through the nanopores embedding, morphology or pore controlling and surface functionalization, nano-porous silica may be an excellent carrier for immediate, controlled and stimuli-responsive drug delivery system. Conclusion Nano-porous silica may have great promising prospective as drug carriers. |
| |
| Keywords: | mesoporous silica silica aerogel drug carrier |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《沈阳药科大学学报》浏览原始摘要信息 |
|
点击此处可从《沈阳药科大学学报》下载全文 |
|
