鲜红斑痣光学测评技术的研究进展

鲜红斑痣（PWS）在病理学上主要表现为先天性的真皮浅层毛细血管网的扩张畸形。血管靶向光动力疗法（V-PDT）是治疗PWS的一种有效方法，在临床应用中，为了不断提高疗效，需要准确判定PWS患者病变靶组织特性（如病变血管深度、管径和血流等），以便为不同患者制定个体化V-PDT治疗方案。近年来，大量研究组致力于开发用于评估PWS病变靶组织结构和功能特性的无创光学测评技术，笔者将在文中综述目前仍处于基础研究阶段以及已经应用于临床评估PWS的光学测评技术，主要包括：光学相干层析成像技术、光声成像技术、反射式共聚焦显微镜、激光多普勒血流成像技术、激光散斑成像技术和空间频域成像技术。

Recent Advances in Optical Imaging Techniques for Clinical Assessment of Port Wine Stains

Port wine stains （PWS） are congenital vascular malformations histologically characterized by ecstatic capillaries predominant in the upper dennis. Vascular-targeted photodynamic therapy （V-PDT） is known to be an effective treatment method for PWS. It is gener- ally recognized that pretreatment knowledge of skin characteristics, such as blood vessel diameter and depth,is helpful for customized selection of treatment parameters, making the therapy more effective. In recent years, several optical imaging techniques have been de- veloped for clinical assessment of PWS skin characteristics. This review focuses on the optical imaging techniques currently in use or under development for PWS assessment, namely, optical coherence tomography, photoaconstic imaging, reflectance confecal microsco- py, laser Doppler imaging, laser speckle imaging and spatial frequency domain imaging.