| MMP-9血清水平及其基因-1562C/T多态性与儿童哮喘关系的研究 |
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| 引用本文： | 朱洪,覃西,林亚妹,谭光宏. MMP-9血清水平及其基因-1562C/T多态性与儿童哮喘关系的研究[J]. 重庆医学, 2011, 40(24): 2407-2409. DOI: 10.3969/j.issn.1671-8348.2011.24.006 |
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| 作者姓名： | 朱洪 覃西 林亚妹 谭光宏 |
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| 作者单位： | 朱洪,覃西,Zhu Hong,Qin Xi(海南医学院附属医院检验科);林亚妹,Lin Yamei(海南医学院附属医院血液透析科,海口,570102);谭光宏,Tan Guanghong(海南医学院海南省热带病原学重点实验室,海口,571101) |
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| 基金项目： | 海南省卫生厅自然科学招标课题 |
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| 摘 要： | 目的 探讨基质金属蛋白酶-9(MMP-9) 血清水平及其基因-1562C/T多态性与儿童哮喘的相关关系.方法 采用双抗体夹心酶联免疫吸附试验(SELISA)测定65例哮喘儿童(病例组)和68名健康对照儿童(对照组)血清MMP-9水平,并采用多聚酶链反应-限制性片段长度多态性(PCR-RFLP)分析技术检测MMP-9基因...
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| 关 键 词： | 基质金属蛋白酶9 儿童 哮喘 |
Study on association of serum matrix metalloproteinase-9 concentration and gene -1562C/T polymorphism to childhood asthma |
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| Zhu Hong,Qin Xi,Lin Yamei,Tan Guanghong. Study on association of serum matrix metalloproteinase-9 concentration and gene -1562C/T polymorphism to childhood asthma[J]. Chongqing Medical Journal, 2011, 40(24): 2407-2409. DOI: 10.3969/j.issn.1671-8348.2011.24.006 |
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| Authors: | Zhu Hong Qin Xi Lin Yamei Tan Guanghong |
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| Affiliation: | Zhu Hong1,Qin Xi1,Lin Yamei2,Tan Guanghong3(1.Department of Clinical Laboratory,Affiliated Hospital of Hainan Medical College,Haikou 570102,China,2.Department of Hemodialysis,Haikou 5710102,3.Hainan Provincial Key Laboratory of Tropical Etiology,Hainan Medical College,Haikou,571101,China) |
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| Abstract: | Objective To explore the association of serum matrix metallproteinase-9(MMP-9) concentration and gene-1562C/T polymorphism to childhood asthma.Methods The serum level of MMP-9 was determined by sandwich enzyme-linked immunosorbent assay(SELISA) method in 65 children with asthma(case group) and 68 healthy children(control group),and the polymorphism of MMP-9 gene-1562C/T was detected by polymerase chain reaction and restriction fragment-length polymorphism(PCR-RFLP) analysis technique.Results The serum level... |
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| Keywords: | matrix metalloproteinase 9 child asthma |
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