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| 胞外pH对中性粒细胞呼吸爆发的影响 | |
| 引用本文： | 李艳玲,刘承宜,段锐,李燕. 胞外pH对中性粒细胞呼吸爆发的影响[J]. 中国病理生理杂志, 2004, 20(4): 683-685 |
| 作者姓名： | 李艳玲 刘承宜 段锐 李燕 |
| 作者单位： | 1. 华南师范大学传输光学实验室信息生物研究室, 广东 广州 510631; 2. 华南师范大学激光运动医学实验室, 广东 广州 510631; 3. 教育部生物医学光子学重点实验室和华中科技大学激光技术国家重点实验室, 湖北 武汉 430074 |
| 基金项目： | 国家自然科学基金(No.60178003，6027812)，广东省自然科学基金团队项目(No.20003061)资助项目，重点项目(No.20011480)，激光技术国家实验室开放基金，广东省“千百十工程”优秀人才培养基金(Q02087)资助项目 |
| 摘 要： | The respiratory burst of neutrophils is an important response in inflammation. The alterations in extracellular pH per se is not a sufficient trigger to the respiratory burst in neutrophils. While neutrophils in respose to conventional agonists, the respiratory burst in neutrophils is affected by the alterations in extracellular pH, and there is a direct relationship between intracellular and extracellular pH. O2 production in neutrophils is decreased while H2O2 production is increased at acidic pH. O2 release in neutrophils is enhanced at weak alkaline pH. Na^ /H^ exchanger plays an important role in the regulation of the respiratory burst of neutrophils. |
| 关 键 词： | 中性白细胞 呼吸爆发 细胞外隙 氢离子浓度 |
| 文章编号： | 1000-4718(2004)04-0683-03 |
| 收稿时间： | 2002-09-27 |
Effects of alterations in extracellular pH on the respiratory burst in neutrophils |
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| LI Yan-ling ,,LIU Cheng-yi ,,DUAN Rui,LI Yan . Effects of alterations in extracellular pH on the respiratory burst in neutrophils[J]. Chinese Journal of Pathophysiology, 2004, 20(4): 683-685 | |
| Authors: | LI Yan-ling LIU Cheng-yi DUAN Rui LI Yan |
| Affiliation: | 1. The Information Biology Group of Laboratory of Light Transmissi on Optics, South China Normal University, Guangzhou 510631, China; 2. Laboratory of Laser Sport Medicine, South China Normal University, Guangzhou 510631, China; 3. The Key Laboratory of Biomedical Photonics of Ministry of Education of China and State Key-Laboratory of Laser Technology, Huazhong University of Science and Technology, Wuhan 430074, China |
| Abstract: | The respiratory burst of neutrophils is an important response in inflammation. The alterations in extracellular pH per se is not a sufficient trigger to the respiratory burst in neutrophils. While neutrophils in respose to conventional agonists, the respiratory burst in neutrophils is affected by the alterations in extracellular pH, and there is a direct relationship between intracellular and extracellular pH. O[SX(B-*3]-[]·[SX)]2 production in neutrophils is decreased while H2O2 production is increased at acidic pH. O[SX(B-*3]-[]·[SX)]2 release in neutrophils is enhanced at weak alkaline pH. Na+/H+ exchanger plays an important role in the regulation of the respiratory burst of neutrophils. |
| Keywords: | Neutrophils Respiratory burst Extracellular space Hydrogenion concentration |
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