| 磷霉素对革兰阴性菌的体外抗菌活性研究 |
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| 引用本文： | 聂大平,马 荣,刘永娥.磷霉素对革兰阴性菌的体外抗菌活性研究[J].大连医科大学学报,2010,32(5):577-579. |
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| 作者姓名： | 聂大平 马 荣 刘永娥 |
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| 作者单位： | 大连医科大学,附属第二医院,检验科,辽宁,大连,116027 |
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| 摘 要： | 目的] 了解磷霉素对革兰阴性菌的体外抗菌活性.方法] 应用K-B纸片扩散法对革兰阴性菌进行体外敏感性实验.结果] 大肠埃希菌、肺炎克雷伯菌、阴沟肠杆菌和产气肠杆菌对磷霉素耐药率为10%～22%;其他肠杆菌、铜绿假单胞菌及鲍曼不动杆菌分别为35%～41%、71%和95%.产ESBLs的大肠埃希菌和肺炎克雷伯菌对磷霉素的耐药率为16%和22%;肺炎克雷伯产酶菌耐药率(22%)明显高于非产酶菌(4%).对磷霉素敏感株而言,磷霉素对大肠埃希菌抑菌环直径远大于肺炎克雷伯菌.结论] 对产ESBLs大肠埃希菌、肺炎雷伯菌、阴沟肠杆菌和产气肠杆菌引起的感染,可选用磷霉素,磷霉素对大肠埃希菌的抗菌活性高于肺炎克雷伯菌.对非发酵菌则不宜选用磷霉素进行临床治疗.
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| 关 键 词： | 革兰阴性菌 磷霉素 耐药性 |
In vitro antimicrobial activity of fosfomycin against gram-negative bacilli |
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| NIE Da-ping,MA Rong and LIU Yong-e.In vitro antimicrobial activity of fosfomycin against gram-negative bacilli[J].Journal of Dalian Medical University,2010,32(5):577-579. |
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| Authors: | NIE Da-ping MA Rong and LIU Yong-e |
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| Institution: | Department of Clinical Laboratory,the Second Affiliated Hospital of Dalian Medical University,Dalian 116027,China;Department of Clinical Laboratory,the Second Affiliated Hospital of Dalian Medical University,Dalian 116027,China;Department of Clinical Laboratory,the Second Affiliated Hospital of Dalian Medical University,Dalian 116027,China |
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| Abstract: | |
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| Keywords: | gram-negative bacilli fosfomycin resistance |
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