伊曲康唑固体脂质纳米粒的体外释放研究

目的：研究伊曲康唑固体脂质纳米粒（ITN）的体外释药行为。方法：采用动态透析法。分别精密吸取ITN混悬液和同浓度的伊曲康唑溶液于预处理过的透析袋中,于（37±1）℃恒温摇床中进行体外释放试验,释放介质为1%吐温80-0.7%浓盐酸（10：7）溶液;采用高效液相色谱法测定伊曲康唑含量;以不同时间取样的累积释药率数据进行不同释药模型的拟合。结果：6h时伊曲康唑溶液几乎释放完全,累积释放率已达到96.32%,释药行为符合一级动力学方程;而ITN仅释放37.93%,其释药行为符合Weibull方程。结论：ITN在体外具有良好的缓释作用。

Drug Release of Itraconazole Solid Lipid Nanoparticles in Vitro

OBJECTIVE：To study the in vitro release of Itraconazole solid lipid nanoparticles（ITN）.METHODS：Dynamic dialysis technology was adopted.ITN suspension and the same concentration of solution were imbibed precisely into the pretreated dialysis bag,and then put it into a conical flask containing 1% tween-80 and 0.7% hydrochloric acid（10：7）solution for the release test in constant temperature shaker of（37±1）℃.The content of itraconazole was determined by HPLC.The fitting of different drug release models were performed based on the accumulative drug release rate.RESULTS：Itraconazole solution released completely in 6 h with accumulative release rate of 96.32%,the drug release behavior was in line with first-order kinetic equation.Release rate of ITN was 37.93%,and drug release curve of it was in line with Weibull equation.CONCLUSION：ITN has satisfactory sustained release effect.