LEPR G1n223Arg多态性对不同种族人群中乳腺癌危险性影响的meta分析

瘦素和瘦素受体参与了乳腺癌的发生发展过程。在瘦素受体基因（LEPR）6号外显子上第223个密码子A到G的转变可以导致谷氨酸到精氨酸的替换（Gln223Arg）。许多已发表的病例对照研究评价了LEPRGln223Arg多态性与乳腺癌的关系。然而，却未得出一致的结论。本篇meta分析囊括了8篇文献来评价LEPRGln223Arg多态性与乳腺癌的联系。用总体合并OR值作为研究共显性模型、隐性模型、显性模型的指标。结果显示总体研究中隐性模型（OR=1．32，95％CI：1．03～1．69）和Arg/Gln vs Gin／Gin基因型（OR=1．16，95％CI：1．01～1．34）显著提高了乳腺癌的危险性。种族分层分析中发现，非洲人群的以下几个基因型会提高患乳腺癌的危险性：Arg/Arg vs 8Gln/Gln（OR=1．86，95％CI：1．28-2．71），Arg／Gln vs GIn/Gln（OR=1．48，95％CI：1．10—1．99），显性模型（OR=1．60，95％CI：1．21～2．11）和隐性模型（OR=1．48，95％cI：1．07～2．05）；亚洲人群中，Arg／ArgvsGin／Gin基因型（OR=6．79，95％CI：3．42～13．47）和显性模型（OR=2．03，95％CI：1．42～2．90）提高了患乳腺癌的危险性。在欧洲人群中任何基因模型都没有发现能显著提高乳腺癌的危险性。总而言之，LEPR223Arg是乳腺癌发展的低风险因素，特别是在非洲女性中。

meta Analysis of Effect ofLEPR G1n223Arg Polymorphism on Breast Cancer Risk in Different Ethnic Populations

Leptin and leptin receptor have been implicated in processes of breast cancer. An A to G transition of codon 223^th in exon 6 of leptin receptor gene （LEPR） can result in the substitution from glutamine to arginine （Gln223Arg）. A variety of case--control papers have been published to evaluate the association between LEPR Gln223Arg polymorphism and breast cancer. However, they have got contradictory conclusions. This meta analysis enrolls 8 papers to evaluate the connection of them. The pooled ORs are took for codominant model, recessive model, dominant model. The result shows that recessive model （OR=1.32, 95%CI： 1.03-1.69） and genotype Arg/Gln vs Gln/Gln （OR=1.16, 95%CI： 1.01-1.34） significantly improve breast cancer risk in overall study. In racial stratified analysis, some genotypes among Africans would significantly increase the risk： Arg/Arg vs Gln/Gln（OR=I.86, 95%CI： 1.28-2.71）, Arg/GIn vs Gln/GIn（OR=l.48, 95%CI： 1.10-1.99）, dominant model（OR=l.60, 95%CI： 1.21-2.11） and recessive model（OR=1.48, 95%CI： 1.07-2.05）; for Asians, Arg/Arg vs GIn/GIn（OR=6.79, 95%C1： 3.42-13.47） and dominant model（OR=2.03, 95%CI： 1.42-2.90）. However, no genetic models are found among Europeans which significantly increase cancer risk. In conclusion, the L1EPR 223Arg is a low risk factor for developing breast cancer, especially for African women.