盐酸西替利嗪治疗常年性变应性鼻炎的临床观察

目的:观察西替利嗪治疗常年性变应性鼻炎(PAR)的疗效及不良反应。方法:给予136例PAR患者每日口服西替利嗪10mg,连续4周,禁用其他抗过敏药或滴鼻剂。结果;随访1年,显效87例(63.97％),有效40例(29.41％),无效9例(6.62％),总有效率93.38％,无严重并发症发生。结论:西替利嗪治疗PAR具有疗效显著,不良反应少等优点,有较好临床应用价值。

Observation of Clinical Efficacy of Cetirizine Hydrochloride in 136 Cases with Perennial Allergic Rhinitis

AIM: The purpose is to study the effect of cetirizine hydrochloride on perennial allergic rhinitis (PAR). METHODS: 136 cases of PAR were treated by cetirizine hydrochloride. Each patient took cetirizine hydrochloride, 10 mg per day for 4-weeks, and other drugs were forbidden. Cetirizine hydrchloride was used for improving the recurrence symptoms in one year follow-up. RESULTS: The overall effective (excellent/good) rate was 93. 38% (excellent 63. 97% , good 29. 41%). Total symptom score (TSS) before treatment and TSS after treatment had significant difference (P<0. 01). The recurrence rate was 68. 38% , but 84 recurrence cases symptoms were lighter than those of pre-treatment. All treatments were well tolerated, and no serious adverse events occurred. CONCLUSION: The curative effect of cetirizine hydrchloride in the treatment for PAR is satisfactory, and the adverse reaction is slight, so it is one of the efficacious antihistamines to treat PAR.