| Viscoelasticity of repaired sciatic nerve by poly（lactic-co-glycolic acid） tubes |
| |
| 引用本文： | Chengdong Piao,Peng Li,Guangyao Liu,Kun Yang. Viscoelasticity of repaired sciatic nerve by poly（lactic-co-glycolic acid） tubes[J]. 中国神经再生研究, 2013, 8(33): 3131-3138. DOI: 10.3969/j.issn.1673-5374.2013.33.007 |
| |
| 作者姓名： | Chengdong Piao Peng Li Guangyao Liu Kun Yang |
| |
| 作者单位： | Department of Orthopedics,Second Hospital,Jilin University;Department of Engineering Mechanics,Nanling Campus,Jilin University;Department of Orthopedics,China-Japan Union Hospital of Jilin University;Base Department,Aviation University of the Air Force of China |
| |
| 摘 要： | Medical-grade synthetic poly（lactic-co-glycolic acid） polymer can be used as a biomaterial for nerve repair because of its good biocompatibility, biodegradability and adjustable degradation rate. The stress relaxation and creep properties of peripheral nerve can be greatly improved by repair with poly（lactic-co-glycolic acid） tubes. ＂Fen sciatic nerve specimens were harvested from fresh corpses within 24 hours of death, and were prepared into sciatic nerve injury models by creating a 10 mm defect in each specimen. Defects were repaired by anastomosis with nerve autografts and poly（lactic-co-glycolic acid） tubes. Stress relaxation and creep testing showed that at 7 200 seconds the sciatic nerve anastomosed by poly（lactic-co-glycolic acid） tubes exhibited a greater decrease in stress and increase in strain than those anastomosed by nerve autografts. These findings suggest that poly（lactic-co-glycolic acid） exhibits good viscoelasticity to meet the biomechanical require- ments for a biomaterial used to repair sciatic nerve injury.
|
| 关 键 词： | 坐骨神经 乙醇酸 粘弹性 乳酸 修复 生物材料 蠕变性能 应力松弛 |
| 收稿时间： | 2013-06-10 |
Viscoelasticity of repaired sciatic nerve by poly(lactic-co-glycolic acid) tubes |
| |
| Chengdong Piao;Peng Li;Guangyao Liu;Kun Yang;. Viscoelasticity of repaired sciatic nerve by poly(lactic-co-glycolic acid) tubes[J]. Neural Regeneration Research, 2013, 8(33): 3131-3138. DOI: 10.3969/j.issn.1673-5374.2013.33.007 |
| |
| Authors: | Chengdong Piao Peng Li Guangyao Liu Kun Yang |
| |
| Affiliation: | Chengdong Piao;Peng Li;Guangyao Liu;Kun Yang;Department of Orthopedics,Second Hospital,Jilin University;Department of Engineering Mechanics,Nanling Campus,Jilin University;Department of Orthopedics,China-Japan Union Hospital of Jilin University;Base Department,Aviation University of the Air Force of China; |
| |
| Abstract: | Medical-grade synthetic poly(lactic-co-glycolic acid) polymer can be used as a biomaterial for nerve repair because of its good biocompatibility, biodegradability and adjustable degradation rate. The stress relaxation and creep properties of peripheral nerve can be greatly improved by repair with poly(lactic-co-glycolic acid) tubes. Ten sciatic nerve specimens were harvested from fresh corpses within 24 hours of death, and were prepared into sciatic nerve injury models by creating a 10 mm defect in each specimen. Defects were repaired by anastomosis with nerve autografts and poly(lactic-co-glycolic acid) tubes. Stress relaxation and creep testing showed that at 7 200 seconds, the sciatic nerve anastomosed by poly(lactic-co-glycolic acid) tubes exhibited a greater decrease in stress and increase in strain than those anastomosed by nerve autografts. These findings suggest that poly(lactic-co-glycolic acid) exhibits good viscoelasticity to meet the biomechanical require-ments for a biomaterial used to repair sciatic nerve injury. |
| |
| Keywords: | neural regeneration peripheral nerve injury sciatic nerve injury model nerve autograftpoly（lactic-co-glycolic acid） transplantation repair stress relaxation creep biomaterialneuroregeneration |
| 本文献已被 CNKI 维普 等数据库收录！ |
