| 6种中草药对小鼠前胃癌变的阻断作用与其硒含量关系的研究 |
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| 引用本文： | 原志庆,杨毅,赵卫,邢丰国,黄冬莲. 6种中草药对小鼠前胃癌变的阻断作用与其硒含量关系的研究[J]. 中国癌症杂志, 1996, 0(1) |
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| 作者姓名： | 原志庆 杨毅 赵卫 邢丰国 黄冬莲 |
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| 作者单位： | 新乡医学院，上蔡县人民医院，开封市第一人民医院，新野县康复医院 |
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| 基金项目： | 河南省中医药管理局资助 |
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| 摘 要： | 目的研究抗癌中草药对癌变的阻断作用及与硒含量的关系。方法采用肌氨酸乙酯盐酸盐（ＮＳＥＥ）诱发的小鼠前胃鳞状上皮癌变模型，观察白花蛇舌草、冬菱草、斑蝥、山豆根、冬虫夏草、乌骨藤等６种中草药对小鼠前胃癌变的阻断作用，同时测定其硒的含量。结果和结论（１）６种中草药对小鼠前胃癌变均有不同程度的阻断作用；（２）６种中草药的癌变抑制率与其硒含量呈直线相关关系。
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| 关 键 词： | 中草药；小鼠；胃；致癌性试验；硒；动物疾病模型 |
RELATIONSHIP BETWEEN BLOCKING EFFECT OF CHINESE MEDICINAL HERBS AND ITS SELENIUM CONTENT ON CARCINOGENESIS IN MICE |
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| Yuan Zhiqing, Yang Yi, Zhao Wei, et al. RELATIONSHIP BETWEEN BLOCKING EFFECT OF CHINESE MEDICINAL HERBS AND ITS SELENIUM CONTENT ON CARCINOGENESIS IN MICE[J]. China Oncology, 1996, 0(1) |
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| Authors: | Yuan Zhiqing Yang Yi Zhao Wei et al |
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| Abstract: | PURPOSE To determine the relationship between the blocking effect of six kinds of Chinese medicinal herbs and its selenium content on the squamous epithelia carcinogenesis in the mouse forestomach.METHODS Using the carcinogenesis model induced by N-nitrososarco-sireethylester (NSEE) in the mouse forestomach. The blocking effect of the herbs on squamous epithelium carcinogenesis were studied in its relation to their selenium content, which was measured by the method of inductively coupled argon plasms (ICP).RESULTS AND CONCLUSIONS It was shown that (1) all of the six kinds of herbs bad a blocking effect on squamous epithelium carcinogenesis in the mouse stomach to varying extents, and (2 ) the herbs'blocking effects had a linear correlation to the herbs'selenium content. |
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| Keywords: | Chinese herbal drugs mice stomach carcinogenecity test selenium animal disease |
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