| 蛋白激酶C与糖尿病性及肥厚性心肌病的研究进展 |
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| 引用本文： | 黄晓莉,孙红霞. 蛋白激酶C与糖尿病性及肥厚性心肌病的研究进展[J]. 医学综述, 2009, 15(21): 3222-3224 |
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| 作者姓名： | 黄晓莉 孙红霞 |
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| 作者单位： | 1. 北华大学医学院机能实验室,吉林,吉林,132013
2. 北华大学药学院药理教研室,吉林,吉林,132013 |
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| 摘 要： | 蛋白激酶C作为第二信使在多条信号通路中发挥着重要作用,并与细胞增殖、分化、凋亡、心肌肥大、心室重塑等有着密切联系。其激活将导致多种心肌病,如糖尿病性心肌病、心肌肥厚和心肌纤维化等心血管疾病的发生。本文对蛋白激酶C与上述几种疾病关系的研究进展予以综述。
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| 关 键 词： | 蛋白激酶C 糖尿病性心肌病 肥厚性心肌病 |
Progresses between Protein Kinase C and Diabetic and Hypertrophic Cardiomyopathy |
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| HUANG Xiao-li,SUN Hong-xia. Progresses between Protein Kinase C and Diabetic and Hypertrophic Cardiomyopathy[J]. Medical Recapitulate, 2009, 15(21): 3222-3224 |
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| Authors: | HUANG Xiao-li SUN Hong-xia |
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| Affiliation: | HUANG Xiao- li ,SUN Hong-xia. ( 1. Department of Organic, Medical College of Beihua University, Jilin 132013, China ; 2. Department of Clinical Pharmacology,Pharmaceeutical College of Beihua University,Jilin 132013,China) |
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| Abstract: | Protein kinase C as second messenger plays an important role in multiple signaling pathway, and closely linked with cell proliferation, differentiation, apoptosis, cardiac hypertrophy, ventricular remodeling. Activation of protein kinase C results in many cardiomyopathy, such as diabetic cardiomyopathy, myocardial hypertrophy and cardiac fibrosis as a biological signal transduction protein for many diseases, this article reviewed its latest study with the above mentioned diseases. |
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| Keywords: | Protein kinase C Diabetic cardiomyopathy Hypertrophic cardiomyopathy |
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