SNCG在结直肠癌肝转移中的表达及其临床意义

目的探讨SNCG在结直肠癌肝转移患者中的表达情况及其临床意义。方法收集1999年1月至2003年12月间中国医学科学院肿瘤医院收治的具有完整临床病理及随访资料的217例结直肠癌手术标本。其中113例伴肝转移,104例无肝转移。采用免疫组织化学染色检测SNCG在结直肠癌组织中的表达。分析SNCG表达与结直肠癌肝转移临床病理特征及预后的关系。结果肝转移组和无肝转移组患者结直肠癌组织中SNCG阳性表达率分别为68．1％（77／113）和27．9％（29／104）,差异有统计学意义（P〈0．05）。Logistic多因素分析显示,SNCG表达是判断结直肠癌是否伴有肝转移的独立因素（OR=8．29,95％CI：3．37～20．37,P〈0．01）。SNCG阳性表达与阴性表达的同时性肝转移患者术后中位生存时间分别为8．2个月和12．6个月．差异有统计学意义（P〈0．05）;Cox多因素分析显示,SNCG表达是结直肠癌同时性肝转移患者的独立预后因素（RR：1．97．95％CI：1．10—3．53,P〈0．05）。结论SNCG在肝转移患者的结直肠癌组织中高表达．SNCG表达不仅可以作为结直肠癌肝转移预示因子,也是同时性肝转移的重要预后因素。

SNCG expression and clinical significance in colorectal cancer liver metastasis

Objective To investigate the expression of SNCG in colorectal cancer with liver metastasis and its clinical significance. Methods Surgical specimens were collected from 217 colorectal cancer patients with complete clinical and follow up data between January 1999 and December 2003. There were 113 cases with liver metastasis and 104 without liver metastasis. SNCG expression was indentified by immunohistochemistry. Association of SNCG expression with clinicopathologic factors and prognosis of colorectal cancer was accessed. Results The positive rate of SNCG in colorectal cancer with and without liver metastasis was 68.1% and 27.9%, respectively, and the difference was statistically signficant （P〈0.05）. Logistic regression analysis showed that SNCG expression was an independent factor associated with the presence of liver metastasis （0R=8.29, 95%CI： 3.37-20.37, P〈 0.01）. In synchronous colorectal liver metastasis, the median survival time of SNCG-negative and SNCG-positive was 12.6 months and 8.2 months, respectively （Log Rank, P〈0.05）. Multivariate Cox analysis showed that SNCG expression was an independent prognostic factor for colorectal cancer with synchronous liver metastasis （RR=l.97, 95%CI： 1.10-3.53, P〈0.05）. Conclusions High expression of SNCG is present in the tumor tissue in patients with liver metastasis from coloreetal cancer. SNCG may be used as a predictive biomarker for colorectal liver metastases and is an important prognostic factor in patients with liver metastasis from colorectal cancer.