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Magnetic resonance imaging of myelin |
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| Authors: | Cornelia Laule Irene M. Vavasour Shannon H. Kolind David K. B. Li Tony L. Traboulsee G. R. Wayne Moore Alex L. MacKay |
| Affiliation: | 1. Department of Radiology, University of British Columbia Hospital, Room M10, Purdy Pavilion/ECU, 2221 Wesbrook Mall, V6T 2B5, Vancouver, BC, Canada 2. Department of Physics and Astronomy, University of British Columbia, V6T 2B5, Vancouver, BC, Canada 3. Department of Medicine, University of British Columbia, V6T 2B5, Vancouver, BC, Canada 4. Department of Pathology & Laboratory and Medicine (Neuropathology), University of British Columbia, V6T 2B5, Vancouver, BC, Canada |
| Abstract: | The ability to measure myelin in vivo has great consequences for furthering our knowledge of normal development, as well as for understanding a wide range of neurological disorders. The following review summarizes the current state of myelin imaging using MR. We consider five MR techniques that have been used to study myelin: 1) conventional MR, 2) MR spectroscopy, 3) diffusion, 4) magnetization transfer, and 5) T2 relaxation. Fundamental studies involving peripheral nerve and MR/histology comparisons have aided in the interpretation and validation of MR data. We highlight a number of important findings related to myelin development, damage, and repair, and we conclude with a critical summary of the current techniques available and their potential to image myelin in vivo. |
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