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| 中药苷类及其代谢产物的脑组织分布研究 | |
| 引用本文： | 宋伟,邬伟魁,张海燕,杨明.中药苷类及其代谢产物的脑组织分布研究[J].中国中药杂志,2012,37(2):152-157. |
| 作者姓名： | 宋伟 邬伟魁 张海燕 杨明 |
| 作者单位： | 1. 江西中医药大学教育部中药现代制剂重点实验室,江西南昌,330004 2. 江西中医药大学教育部中药现代制剂重点实验室,江西南昌330004;西南交通大学教育部先进材料技术重点实验室,四川成都610003 3. 江西中医药大学教育部中药现代制剂重点实验室,江西南昌330004;成都中医药大学,四川成都611137 |
| 基金项目： | 中医药行业科研专项(200708006);国家"重大新药创制"科技重大专项(2009ZX09103-393,2009ZX09310-005) |
| 摘 要： | 很多中药有效成分以苷的形式存在,近年来,中药苷类生物利用度低的问题引起了广泛关注。经不同途径给药后苷类及其代谢产物的组织分布情况直接影响其疗效。随着中药苷类用于脑部疾病防治的报道日益增多,苷类的脑组织分布规律研究显得尤为重要。据报道,苷在体内各组织广泛分布,有些苷可以到达脑组织,有些苷却不能进入脑组织。该研究对苷类及其代谢产物对脑部疾病的作用、在脑组织的分布情况和剂型对药物脑组织分布影响的近年报道进行了综述,以期为该类中药在脑部疾病防治中的研究及其新药研发提供一定的参考。 |
| 关 键 词： | 中药 苷类 苷元 代谢产物 脑组织 |
| 收稿时间： | 2011/4/18 0:00:00 |
Study on herbal drugs of glycosides in brain |
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| SONG Wei,WU Weikui,ZHANG Haiyan and YANG Ming.Study on herbal drugs of glycosides in brain[J].China Journal of Chinese Materia Medica,2012,37(2):152-157. | |
| Authors: | SONG Wei WU Weikui ZHANG Haiyan and YANG Ming |
| Institution: | Key Laboratory of Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China;Key Laboratory of Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China;Key Laboratory of Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China;Key Laboratory of Advanced Technology of Materials, Ministry of Education, Southwest Jiaotong University, Chengdu 610003, China;Key Laboratory of Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China;Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China |
| Abstract: | Many active ingredients in traditional Chinese medicine exist in the form of glycosides. In recent years, the problem of low bioavailability of Chinese glycosides has caused wide public concern. Glycosides and their metabolites organization distribution directly affect glycosides' curative effect after different ways administration. With reports of glycosides medicine for prevention and treatment of brain diseases increasing, the research of glycosides brain tissue distribution is particularly important. According to reports, glycosides widely distributed in tissues, some glycosides can reach the brain, but some glycosides can not. This research reviews glycosides and their metabolites on the role of brain diseases, the distribution in the brain tissue and recent reports of dosage form's effect to brain. So it can provide a reference for the period of such medicine in the prevention and treatment of brain diseases and drug development. |
| Keywords: | traditional Chinese medicine glycosides aglycones metabolites brain tissue |
| 本文献已被 CNKI 万方数据 PubMed 等数据库收录！ | |