| 基于体内ADME过程和网络药理学的中药现代研究思路 |
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| 引用本文： | 许海玉,黄璐琦,卢鹏,杨洪军. 基于体内ADME过程和网络药理学的中药现代研究思路[J]. 中国中药杂志, 2012, 37(2): 142-145 |
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| 作者姓名： | 许海玉 黄璐琦 卢鹏 杨洪军 |
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| 作者单位： | 1. 中国中医科学院中药研究所,北京,100700
2. 中国中医科学院中药研究所,北京100700;中国科学院自动化研究所,北京100190 |
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| 基金项目： | 国家科技支撑计划项目(2008BAI51B03);中医药行业科研专项(200907001-5);中国中医科学院基本科研业务费自主选题项目(Z02063);国家工程实验室科技项目(655-30) |
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| 摘 要： | 网络药理学应用到中药研究中,有利于阐释中药药效物质基础和作用机制,提高中药新药的研发水平,但是,鉴于中药有效物质的复杂性特点,进行体内过程分析,明确进入体内的成分,是将网络药理学应用于中药研究的前提。为此,提出体内ADME过程与网络药理学相结合的中药现代研究思路。
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| 关 键 词： | 网络药理学 体内ADME过程 方剂代谢指纹 药代标示物 |
| 收稿时间： | 2011-11-20 |
Application of ADME process in vivo in combination with network pharmacology in study of traditional Chinese medicine |
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| XU Haiyu,HUANG Luqi,LU Peng and YANG Hongjun. Application of ADME process in vivo in combination with network pharmacology in study of traditional Chinese medicine[J]. China Journal of Chinese Materia Medica, 2012, 37(2): 142-145 |
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| Authors: | XU Haiyu HUANG Luqi LU Peng YANG Hongjun |
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| Affiliation: | Institute of Chinese Material Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Institute of Chinese Material Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Institute of Chinese Material Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China;Institute of Chinese Material Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China |
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| Abstract: | Application of network pharmacology in traditional Chinese medicine(TCM) will be benefit for clarifying active components and mechanism of action of TCM and increase the study level of new drug of Chinese medicine. ADME process can identify drug components from TCM and obtain the possible metabolites which can clarify active components in vivo. For the complexity of active constituents of TCM, it indicated that the ADME process will be the precondition for application of network pharmacology in TCM. This paper introduced the study ideas of the combination of ADME process in vivo and network pharmacology. |
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| Keywords: | network pharmacology ADME process in vivo metabolic fingerprints pharmacokinetic markers |
| 本文献已被 CNKI 万方数据 PubMed 等数据库收录！ |
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