| 连翘果实中的化学成分研究 |
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| 引用本文： | 邹琼宇,邓文龙,蒋舜媛,张磊,彭树林,丁立生.连翘果实中的化学成分研究[J].中国中药杂志,2012,37(1):57-60. |
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| 作者姓名： | 邹琼宇 邓文龙 蒋舜媛 张磊 彭树林 丁立生 |
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| 作者单位： | 1. 中国科学院成都生物研究所,四川成都,610041
2. 四川省中医药科学院中药材品质与创新中药四川省重点实验室,四川成都,610041 |
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| 基金项目： | 国家"重大新药创制"科技重大专项(2009ZX09103-439);国家重点基础研究发展计划(973)项目(2007CB512604) |
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| 摘 要： | 目的:更全面地阐明中药连翘的活性物质基础.方法:利用多种色谱方法分离连翘Forsythia suspensa果实的化学成分,并通过ESI-MS/MS及1D-和2D-NMR等波谱方法鉴定出24种化合物,它们的结构类型分别属于木脂素、黄酮、环己乙醇衍生物、三萜和神经酰胺.结果和结论:发现化合物1～10为首次从中药连翘果实中分离得到的神经酰胺类化合物,其中1,2,4,5的结构为首次报道.
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| 关 键 词： | 连翘 神经酰胺 分离鉴定 |
| 收稿时间： | 2011/6/23 0:00:00 |
Studies on chemical constituents from fruits of Forsythia suspense |
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| ZOU Qiongyu,DENG Wenlong,JIANG Shunyuan,ZHANG Lei,PENG Shulin and DING Lisheng.Studies on chemical constituents from fruits of Forsythia suspense[J].China Journal of Chinese Materia Medica,2012,37(1):57-60. |
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| Authors: | ZOU Qiongyu DENG Wenlong JIANG Shunyuan ZHANG Lei PENG Shulin and DING Lisheng |
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| Institution: | Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China;Sichuan Key Laboratory of Quality and Innovation Research of Chinese Materia Medica, Sichuan Academy of Chinese Medicine Sciences, Chengdu 610041, China;Sichuan Key Laboratory of Quality and Innovation Research of Chinese Materia Medica, Sichuan Academy of Chinese Medicine Sciences, Chengdu 610041, China;Sichuan Key Laboratory of Quality and Innovation Research of Chinese Materia Medica, Sichuan Academy of Chinese Medicine Sciences, Chengdu 610041, China;Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China;Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China |
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| Abstract: | Twenty-four compounds in the fruits of Forsythia suspensa were isolated and purified by column chromatography and preparative TLC. On the basis of comprehensive spectroscopic methods including IR, ESI-MS/MS, 1D and 2D NMR, these compounds were identified as ten ceremides( 1-10 ), six triterpenes( 11-16 ), one steroids( 17 ), three flavonoids( 18-20 ), two C6-C2 alcohols( 21-22 )and two lignans( 23-24 ). Compounds 1-10 were reported from F. suspense for the first time, among which 1, 2, 4 and 5 were new ones. |
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| Keywords: | Forsythia suspensa ceremide isolation and identification |
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