| 小细胞肺癌化疗耐药研究进展 |
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| 引用本文： | 陈一天,封冰. 小细胞肺癌化疗耐药研究进展[J]. 医学研究生学报, 2012, 25(5): 515-519 |
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| 作者姓名： | 陈一天 封冰 |
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| 作者单位： | 南京军区南京总医院肿瘤内科,南京,210002 |
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| 摘 要： | 小细胞肺癌(small cell lung cancer,SCLC)细胞倍增时间短,病情进展快,早期即发生血道和淋巴道转移,恶性程度在所有肺癌类型中最高.尽管SCLC对放、化疗呈现出较好的初始反应性,但很快即产生复发或病情进展.耐药形成,尤其是多药耐药(multidrug resistance,MDR)的产生是SCLC化疗失败的最重要原因.文中就近年来对SCLC耐药机制及其逆转策略的研究进展作一综述.
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| 关 键 词： | 小细胞肺癌 化疗耐药 靶向治疗 |
Research on chemoresistance of small cell lung cancer |
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| CHEN Yi-tian , FENG Bing. Research on chemoresistance of small cell lung cancer[J]. Bulletin of Medical Postgraduate, 2012, 25(5): 515-519 |
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| Authors: | CHEN Yi-tian FENG Bing |
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| Affiliation: | checking(Department of Oncology,Nanjing General Hospital of Nanjing Military Command,PLA,Nanjing 210002,Jiangsu,China) |
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| Abstract: | Small cell lung cancer(SCLC) is characterized by a short cell doubling time,quick progression of the condition and early occurrence of blood-borne and lymph metastasis.The malignancy of SCLC is the highest of all lung cancer types.Although SCLC has a relatively good initial response to radiochemotherapy,relapse or disease progression may occur quickly.Drug resistance,especially multi-drug resistance,is the most important cause for failure of SCLC chemotherapy.This article is a review of the update of research on mechanisms of drug resistance in SCLC and reversal strategies. |
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| Keywords: | Small cell lung cancer Chemoresistance Targeted therapy |
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